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  1. FDA approves new drug for relapsed or refractory AML

    ... of patients were nausea, vomiting, diarrhea, elevated bilirubin , and decreased appetite. Differentiation syndrome occurred in 14% ...

    Article last updated 08/30/2017 - 8:30am.

  2. A retrospective study of paroxysmal nocturnal hemoglobinuria in pediatric and adolescent patients

    ... first group of patients had higher levels of LDH, total bilirubin and absolute reticulocyte count and a bigger PNH ...

    Research Article last updated 05/02/2017 - 10:42am.

  3. Diagnosis

    ... with PNH to have LDH monitored regularly. A bilirubin test measures the total amount of this substance in your blood. ...

    Topic section last updated 03/10/2016 - 11:04pm.

  4. Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation

    ... by: Hepatic: < 3x ULN ALT and < 1.5 total serum bilirubin , unless there is congenital benign hyperbilirubinemia. Renal: ... by: Hepatic: < 3x ULN ALT and < 1.5 total serum bilirubin , unless there is congenital benign hyperbilirubinemia. Renal: ...

    Clinical Trial last updated 04/29/2016 - 1:11pm.

  5. Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

    ... detectable CH50 activity (CH50>10%) (p=0.004), elevated bilirubin levels (p<0.0001), and the need for transfusions (p=0.034). This ...

    Research Article last updated 01/20/2015 - 2:28pm.

  6. A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Hematologic Malignancies with an IDH1 Mutation

    ... considered due to leukemic disease and serum total bilirubin ≤1.5 x upper limit of normal (ULN), unless considered due to ...

    Clinical Trial last updated 02/22/2017 - 11:21am.

  7. AML Therapy With Irradiated Allogeneic Cells

    ... of AML in patient >= 60 years old Total bilirubin =< 1.5 times upper limit of normal (ULN) institutional limits ... of patient adverse effects or poor outcomes Total bilirubin < 1.5 times upper limit of normal (ULN) institutional limits (unless ...

    Clinical Trial last updated 06/13/2016 - 3:14pm.

  8. Fludarabine/Clofarabine/Busulfan Combined With SAHA in Acute Leukemia

    ... Estimated creatinine clearance at least 50 ml/min. Bilirubin equal or less than 1.5 (unless Gilbert's Syndrome), SGPT <3 X ...

    Clinical Trial last updated 06/06/2016 - 11:07am.

  9. Dose Escalation of OXi4503 as Single Agent and Combination With Cytarabine w/Subsequent Ph 2 Cohorts for AML and MDS (AML)

    ... Oncology Group performance status 0, 1, or 2 Total bilirubin ≤ 2 Serum aspartate aminotransferase (AST) and alanine ...

    Clinical Trial last updated 05/02/2016 - 11:06am.

  10. Unrelated Donor Stem Cell Transplantation

    ... > 40ml/min Transaminases < 2X normal Total bilirubin < 2X normal HIV seronegativity Weight < 70kg for cord ...

    Clinical Trial last updated 04/28/2016 - 2:16pm.