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  1. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... normal practice for such subject. History of autoimmune disorder (e.g. hepatitis; ITP; scleroderma; severe psoriasis ...

    Clinical Trial last updated 04/29/2016 - 9:59am.

  2. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... Acquired aplastic anemia (aAA) is a nonmalignant disease caused by autoimmune destruction of early hematopoietic cells. Clonal hematopoiesis ...

    Research Article last updated 04/07/2015 - 1:05pm.

  3. Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.

    ... bone marrow failure syndrome, caused by autoimmune destruction of hematopoietic stem and progenitor cells. ... exposures and metabolic gene polymorphisms contribute to disease pathogenesis. Several case-control studies linked homozygous deletion ...

    Research Article last updated 07/09/2013 - 2:58pm.

  4. Epidemiology and risk factors for infections in myelodysplastic syndromes.

    ... 95% CI = 1.2-2.7, P < 0.007), chronic obstructive pulmonary disease (HR = 2.6, 95% CI = 1.4-4.9, P < 0.003), history of other malignancy (HR 2.0, 95% CI = 1.3-3.1, P < 0.003), and autoimmune disease (HR 2.9, 95% CI = 1.4-6.0, P < 0.005). Age, nadir ...

    Research Article last updated 09/17/2013 - 2:12pm.

  5. Immunosuppression and Stem Cell Transplantation – How Are These Treatments Chosen?

    ... 80% of aplastic anemia patients, the underlying cause of the disease is immunologic – it’s an autoimmune disease . As with other autoimmune diseases like multiple ...

    Interview last updated 07/15/2015 - 10:19am.

  6. Rabbit-antithymocyte globulin combined with cyclosporin A as a first-line therapy: improved, effective, and safe for children with acquired severe aplastic anemia.

    ... Acquired aplastic anemia is an organ-specific auto-immune disease characterized by pancytopenia and hypoplastic bone marrow ...

    Research Article last updated 06/15/2012 - 2:50pm.

  7. Are T-cell dysfunctions the other side of the moon in the pathogenesis of myelodysplastic syndromes?

    ... review, we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus ... of T-cell activation and their implications in the disease history. The potential impact of specific cell subsets, such as ...

    Research Article last updated 06/15/2012 - 2:09pm.

  8. Th17 immune responses contribute to the pathophysiology of aplastic anemia.

    ... production of interleukin-17 (IL-17) and association with autoimmune diseases. We studied the role of Th17 cells in aplastic anemia ... (P = .0007 and .02, respectively) and correlated with disease activity. There was an inverse relationship between the numbers of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Rosario Notaro, MD

    ... the notion that these cells are prime movers of the disease and therefore may make it possible to develop new forms of ... GPI-reactive T cells, which are likely responsible for the auto-immune attack to the normal (GPI+) hematopoiesis , is affected by ...

    Grant Recipient last updated 10/14/2015 - 9:28am.

  10. 2014 Scholarships Awarded to Special Group of Young People

    ... by PNH. They have survived difficult treatments for their disease and through their own determination and hard work have positioned ... years my health was pretty stable. Then myocarditis, another auto-immune disorder caused by heart to stop seven times in one day. My ...

    Page last updated 10/22/2015 - 8:28am.