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  1. Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... hydrocortisone less than 12 mg/m^2/day Active autoimmune disease requiring systemic immunosuppressive therapy ...

    Clinical Trial last updated 07/14/2016 - 4:08pm.

  2. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... from leukapheresis or G-CSF therapy (e.g., active autoimmune disease , sickle cell trait, symptomatic coronary artery disease ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  3. AK579 (COBALT)

    ... Bone Marrow Disease(s):  paroxysmal nocturnal hemoglobinuria (PNH) ... (e.g. bee or wasp venom) History of active systemic autoimmune diseases other than the target condition. Dermatologic diseases such ...

    Clinical Trial last updated 09/14/2016 - 10:39am.

  4. Pure Red Cell Aplasia (PRCA)

    ... cases have been reported worldwide. The severity of the disease varies by patient. Relation to bone marrow failure ... cause of most cases of PRCA is most recently thought to be autoimmune in nature. Doctors think it is caused by a mistaken attack by the ...

    Topic section last updated 07/07/2016 - 3:14pm.

  5. An Open-label Study of Lirilumab (BMS-986015) in Combination With 5-azacytidine (Vidaza) for the Treatment of Patients With Refractory/ Relapsed Acute Myeloid Leukemia

    ... to learn if the drug combination can help to control the disease. The safety of the drug combination will also be studied. ... Patients with a known history of any of the following autoimmune diseases are excluded: (a) patients with a history of inflammatory ...

    Clinical Trial last updated 06/06/2016 - 1:26pm.

  6. Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCT (RIC HSCT NMD)

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... syndrome IPEX syndrome Chediak -Higashi Syndrome Autoimmune Lymphoproliferative Syndrome (ALPS) Hemophagocytic ...

    Clinical Trial last updated 06/13/2016 - 2:18pm.

  7. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... may help stop a side effect called Graft-Versus-Host Disease (GVHD) . Some studies have been done with CliniMACS, but the Food ... CD40 ligand deficiency, or ALPS, as well as refractory autoimmune cytopenias, PNH, metabolic storage diseases or heavily transfused ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  8. Kathryn (Kate) Bauer, Retired MDS Patient Living Life to the Fullest Since Transplant

    ... multiple post-transplant problems such as graft versus host disease and four compression fractures from the steroids. But I was alive, ... the mouth and skin. It has progressed to scleroderma, an autoimmune disease characterized by hardening of the skin.  But, with the ...

    Patient Chronicle last updated 07/23/2015 - 9:38am.

  9. Role of microRNAs in Aplastic Anemia

    ... healthy people and from patients with MDS or sickle cell disease. Key findings: miRNAs were downregulated, meaning that ... the role of these miRNAs in the more general development of autoimmune diseases.   ...

    Research Review last updated 05/02/2016 - 9:15am.

  10. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... normal practice for such subject.     History of autoimmune disorder (e.g. hepatitis)     Hypersensitivity to interferon ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.