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  1. MEDALIST Trial

    ... Tue, 06/25/2019 Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... vitamin B12 , or folate deficiencies, or autoimmune or hereditary hemolytic anemia, or gastrointestinal bleeding - ...

    Clinical Trial last updated 02/22/2017 - 11:42am.

  2. Causes

    ... aplastic anemia is usually considered an autoimmune disease . Normally, your immune system attacks only foreign substances. When ...

    Topic section last updated 06/30/2016 - 9:46am.

  3. MDS and Inflammation

    ... They appear to have a very important role in the disease biology and this signaling occurs through a protein complex called the ... whether it is asthma, rheumatoid arthritis, or some sort of autoimmune disorder, had a much higher risk of developing MDS. MDS patients can ...

    Interview last updated 02/14/2017 - 8:52am.

  4. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... Anastasios Karadimitris Aplastic anemia is a disease where the patients’ immune system attacks his or her own bone ... it has been believed that PNH should be considered an autoimmune disease for a different reason—because it occurs commonly in ...

    Research Review last updated 05/02/2016 - 9:26am.

  5. Immunosuppression and Stem Cell Transplantation – How Are These Treatments Chosen?

    ... 80% of aplastic anemia patients, the underlying cause of the disease is immunologic – it’s an autoimmune disease . As with other autoimmune diseases like multiple ...

    Interview last updated 07/15/2015 - 10:19am.

  6. Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

    ... inhibitor (CNI)-free strategies for Graft-versus-Host Disease (GVHD) prophylaxis to standard tacrolimus and methotrexate ... year after transplantation History of uncontrolled autoimmune disease or on active treatment Patients with prior ...

    Clinical Trial last updated 06/06/2016 - 1:36pm.

  7. Interviews with the Experts: Dr. Bart Scott on PNH

    ... it’s hard to design a clinical trial to study the disease in a comprehensive manner. So few have it, and they are dispersed ... failure . We know that aplastic anemia patients have an autoimmune process where the bone marrow stem cells are attacked by the ...

    Interview last updated 09/23/2016 - 2:33pm.

  8. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... Tue, 03/01/2016 Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... cells by spinal fluid will be eligible Known active autoimmune disorder Known to be human immunodeficiency virus (HIV)-positive ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.

  9. Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    ... Fri, 12/01/2017 Bone Marrow Disease(s):  myelodysplastic syndromes (MDS) ... hydrocortisone less than 12 mg/m^2/day Active autoimmune disease requiring systemic immunosuppressive therapy ...

    Clinical Trial last updated 07/14/2016 - 4:08pm.

  10. AK579 (COBALT)

    ... Fri, 06/30/2017 Bone Marrow Disease(s):  paroxysmal nocturnal hemoglobinuria (PNH) ... (e.g. bee or wasp venom) History of active systemic autoimmune diseases other than the target condition. Dermatologic diseases such ...

    Clinical Trial last updated 09/14/2016 - 10:39am.