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  1. Myelodysplastic Syndromes in Adolescent Young Adults: One Institution's Experience

    ... patients, aged 18 to 39 years, possibly reflecting different disease biology. Myelodysplastic syndrome (MDS) is mainly a disease of the ... more circulating myeloblasts, and more hypoplastic MDS. Autoimmune disorders were more prevalent in older patients. The median overall ...

    Research Article last updated 09/19/2016 - 11:09am.

  2. Epidemiology and risk factors for infections in myelodysplastic syndromes.

    ... 95% CI = 1.2-2.7, P < 0.007), chronic obstructive pulmonary disease (HR = 2.6, 95% CI = 1.4-4.9, P < 0.003), history of other malignancy (HR 2.0, 95% CI = 1.3-3.1, P < 0.003), and autoimmune disease (HR 2.9, 95% CI = 1.4-6.0, P < 0.005). Age, nadir ...

    Research Article last updated 09/17/2013 - 2:12pm.

  3. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disease that has been investigated for over one century and has revealed unique ... that expansion of the PNH clone results from T-cell-mediated auto-immune damage to hematopoietic stem cells , with the GPI molecule ...

    Research Article last updated 06/07/2016 - 10:56am.

  4. AAMDSIF Summer Fellowship Grant Program

    ... is a bone marrow failure disorder, and it is a devastating disease that can have a rapid onset with an often unclear cause. Aplastic anemia has been shown to have a strong association with autoimmune and inflammatory disorders, in which immune cells attack normal ...

    Page last updated 05/17/2017 - 1:29pm.

  5. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... Myelodysplastic Syndromes (MDS) and autoimmune disorders (AD): Cause or consequence? ... with both MDS and AD – other than trisomy 8 in Behcet’s disease. It is unknown if AD have an impact on overall survival in MDS ...

    Research Review last updated 05/02/2016 - 9:18am.

  6. Th17 immune responses contribute to the pathophysiology of aplastic anemia.

    ... production of interleukin-17 (IL-17) and association with autoimmune diseases. We studied the role of Th17 cells in aplastic anemia ... (P = .0007 and .02, respectively) and correlated with disease activity. There was an inverse relationship between the numbers of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Rabbit-antithymocyte globulin combined with cyclosporin A as a first-line therapy: improved, effective, and safe for children with acquired severe aplastic anemia.

    ... Acquired aplastic anemia is an organ-specific auto-immune disease characterized by pancytopenia and hypoplastic bone marrow ...

    Research Article last updated 06/15/2012 - 2:50pm.

  8. Are T-cell dysfunctions the other side of the moon in the pathogenesis of myelodysplastic syndromes?

    ... review, we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus ... of T-cell activation and their implications in the disease history. The potential impact of specific cell subsets, such as ...

    Research Article last updated 06/15/2012 - 2:09pm.

  9. Anastasios Karadimitris, MD, PhD

    ... anemia (IAA). Both disorders are considered to have an autoimmune mechanism involving auto-reactive T cells targeting hematopoietic ... Haemoglobinuria (PNH) is a bone marrow failure  disease in which there is a severe depletion of haematopoietic stem cells ...

    Grant Recipient last updated 03/07/2017 - 9:50am.

  10. Dr. Kasiani Myers: Acquired and Inheirited Bone Marrow Failure

    ... between acquired and inherited bone marrow failure disease? Hereditary bone marrow failure results from a genetic ... aplastic anemia is thought to be primarily an autoimmune, or immune-mediated disorder. So a trigger of some kind sets off the ...

    Interview last updated 02/14/2017 - 8:34am.