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  1. Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.

    ... bone marrow failure syndrome, caused by autoimmune destruction of hematopoietic stem and progenitor cells. ... exposures and metabolic gene polymorphisms contribute to disease pathogenesis. Several case-control studies linked homozygous deletion ...

    Research Article last updated 07/09/2013 - 2:58pm.

  2. Strong results for SAA patients at Johns Hopkins

    ... 16 aplastic anemia patients free of disease after bone marrow transplant and chemo ... blood transfusions, take multiple medicines to suppress the autoimmune response that damages the marrow, take other drugs to prevent ...

    Article last updated 02/07/2017 - 11:05am.

  3. Epidemiology and risk factors for infections in myelodysplastic syndromes.

    ... 95% CI = 1.2-2.7, P < 0.007), chronic obstructive pulmonary disease (HR = 2.6, 95% CI = 1.4-4.9, P < 0.003), history of other malignancy (HR 2.0, 95% CI = 1.3-3.1, P < 0.003), and autoimmune disease (HR 2.9, 95% CI = 1.4-6.0, P < 0.005). Age, nadir ...

    Research Article last updated 09/17/2013 - 2:12pm.

  4. The immune landscape of myelodysplastic syndromes

    ... review we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus ... influence of different immune cell subpopulations on the disease onset and evolution. We will finally consider therapeutic approaches ...

    Research Article last updated 11/28/2016 - 9:37am.

  5. Myelodysplastic Syndromes in Adolescent Young Adults: One Institution's Experience

    ... patients, aged 18 to 39 years, possibly reflecting different disease biology. Myelodysplastic syndrome (MDS) is mainly a disease of the ... more circulating myeloblasts, and more hypoplastic MDS. Autoimmune disorders were more prevalent in older patients. The median overall ...

    Research Article last updated 09/19/2016 - 11:09am.

  6. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disease that has been investigated for over one century and has revealed unique ... that expansion of the PNH clone results from T-cell-mediated auto-immune damage to hematopoietic stem cells , with the GPI molecule ...

    Research Article last updated 06/07/2016 - 10:56am.

  7. Th17 immune responses contribute to the pathophysiology of aplastic anemia.

    ... production of interleukin-17 (IL-17) and association with autoimmune diseases. We studied the role of Th17 cells in aplastic anemia ... (P = .0007 and .02, respectively) and correlated with disease activity. There was an inverse relationship between the numbers of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Rabbit-antithymocyte globulin combined with cyclosporin A as a first-line therapy: improved, effective, and safe for children with acquired severe aplastic anemia.

    ... Acquired aplastic anemia is an organ-specific auto-immune disease characterized by pancytopenia and hypoplastic bone marrow ...

    Research Article last updated 06/15/2012 - 2:50pm.

  9. Are T-cell dysfunctions the other side of the moon in the pathogenesis of myelodysplastic syndromes?

    ... review, we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus ... of T-cell activation and their implications in the disease history. The potential impact of specific cell subsets, such as ...

    Research Article last updated 06/15/2012 - 2:09pm.

  10. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... Myelodysplastic Syndromes (MDS) and autoimmune disorders (AD): Cause or consequence? ... with both MDS and AD – other than trisomy 8 in Behcet’s disease. It is unknown if AD have an impact on overall survival in MDS ...

    Research Review last updated 05/02/2016 - 9:18am.