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  1. The different immunoregulatory functions of mesenchymal stem cells in patients with low-risk or high-risk myelodysplastic syndromes

    ... with the presence of increased TGF-β1, higher apoptosis , higher immunosuppressive rate and a poor ability of ...

    Research Article last updated 11/05/2012 - 10:25am.

  2. Molecular and genetic features of myelodysplastic syndromes.

    ... hematopoiesis in MDS has been the varying degrees of apoptosis of the hematopoietic precursors and their progeny. A variety of ...

    Research Article last updated 04/24/2012 - 2:43pm.

  3. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

    ... CONTEXT: Critically short telomeres produce apoptosis , cell senescence, and chromosomal instability in tissue culture ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Therapeutic modalities for patients with lower-risk myelodysplastic syndromes: current options and future directions.

    ... aimed at promoting hematopoiesis , inhibiting apoptosis , and reducing the risk of transformation to acute myeloid ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Myelodysplastic syndromes: an update on molecular pathology.

    ... is a significant increase in programmed cell death ( apoptosis ) in haematopoietic cells. Furthermore, altered responses in ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.

    ... suppressed T-cell proliferation and induced T-cell apoptosis in allogeneic cocultures. When fresh bone marrow samples from ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Lenalidomide for treatment of myelodysplastic syndromes: current status and future directions.

    ... cdc25c, thereby promoting selective G2 arrest and apoptosis . In non-del(5q) patients, lenalidomide enhances ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Decitabine in the treatment of myelodysplastic syndromes.

    ... genes, leading to cellular differentiation and/or apoptosis . Decitabine is a cytidine analogue that has activity as ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. The molecular pathogenesis of myelodysplastic syndromes.

    ... regulation, microenvironment interactions, regulation of apoptosis and oxidative damage/DNA repair may all play an important ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromes

    ... MAPK over-activation may contribute to the increasing apoptosis of marrow cells, a phenomenon commonly observed in MDS, and lead ...

    Research Article last updated 06/15/2012 - 1:19pm.