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  1. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes

    ... division and preventing from premature senescence and apoptosis . The rate-limiting component of telomerase is human telomerase ...

    Research Article last updated 06/02/2014 - 10:45am.

  2. Integrating genetics and epigenetics in myelodysplastic syndromes: advances in pathogenesis and disease evolution

    ... characterized by inefficient haematopoiesis, increased apoptosis and risk of evolution to acute myeloid leukaemia. Alterations in ...

    Research Article last updated 06/19/2014 - 1:07pm.

  3. Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy

    ... kinase pathways that induces mitotic arrest and apoptosis in neoplastic cells, while sparing normal cells. Our purpose is ...

    Research Article last updated 05/22/2014 - 10:23am.

  4. Sicheng Wen, MD, PhD

    ... in vitro and in vivo by inhibition of DNA damage and apoptosis . In this study, we evaluated whether human MSC-EVs could reverse ...

    Grant Recipient last updated 01/05/2018 - 1:09pm.

  5. The complex pathophysiology of acquired aplastic anemia

    ... and tumor growth factor -beta (TGF-β), induce apoptosis of HSPCs, constituting a consistent and defining feature of ...

    Research Article last updated 03/03/2015 - 11:32am.

  6. Immunological derangement in hypocellular myelodysplastic syndromes

    ... overexpression of FAS-L and of the TNF-related apoptosis -inducing ligand (TRAIL), underexpression of Flice-like inhibitory ...

    Research Article last updated 05/22/2014 - 9:53am.

  7. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... Subsequent to P53 activation, erythroid cell apoptosis and ineffective erythropoiesis occur. Other pathogenetic ...

    Research Article last updated 04/17/2014 - 11:29am.

  8. Myelodysplastic Syndromes (MDS) and autoimmune disorders (AD): Cause or consequence?

    ... factor-(TNF)-α and interferon (IF)-γ triggers apoptosis of myeloid precursor cells leading to cytopenias. Impaired ...

    Research Article last updated 03/06/2014 - 11:52am.

  9. Key clinical observations after 5-azacytidine and decitabine treatment of myelodysplastic syndromes suggest practical solutions for better outcomes

    ... of p53, thus circumventing a basis for resistance to apoptosis -based DNA-damaging therapy. That responses cut across the chaotic ...

    Research Article last updated 01/08/2014 - 9:30am.

  10. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... DNA damage response and result in cellular senescence or apoptosis . In the setting of failed checkpoint mechanisms, such DNA-protein ...

    Research Article last updated 08/07/2013 - 9:19am.