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  1. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... responses can induce bone marrow failure due to apoptosis . Due to increased production of these cytokines and impaired ...

    Research Review last updated 05/02/2016 - 9:18am.

  2. Pathogenesis of MDS: An overview of molecular and non-molecular aspects of the disease

    ... MDS is transcription of genes and cell cycle progression/ apoptosis , and genes involved in this pathway include RUNX1, TP53, and ... factors associated with the bone marrow microenvironment, apoptosis, cytokines, telomere length, and immune factors.  ...

    Research Review last updated 05/02/2016 - 9:14am.

  3. The complex pathophysiology of acquired aplastic anemia

    ... and tumor growth factor -beta (TGF-β), induce apoptosis of HSPCs, constituting a consistent and defining feature of ...

    Research Article last updated 03/03/2015 - 11:32am.

  4. The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes.

    ... of tumor necrosis factor α (TNFα) and up-regulation of apoptosis in the marrow. In contrast, marrow cells in advanced MDS are typically resistant to TNFα-induced apoptosis but are rendered apoptosis-sensitive on coculture with stroma. The ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Integrating genetics and epigenetics in myelodysplastic syndromes: advances in pathogenesis and disease evolution

    ... characterized by inefficient haematopoiesis, increased apoptosis and risk of evolution to acute myeloid leukaemia. Alterations in ...

    Research Article last updated 06/19/2014 - 1:07pm.

  6. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes

    ... division and preventing from premature senescence and apoptosis . The rate-limiting component of telomerase is human telomerase ...

    Research Article last updated 06/02/2014 - 10:45am.

  7. The myelodysplastic syndrome as a prototypical epigenetic disease.

    ... aberrant differentiation resulting in a high rate of apoptosis and eventual symptoms related to bone marrow failure . ... growth-controlling genes that seem to tip the proliferation/apoptosis balance and result in the development of acute myelogenous ...

    Research Article last updated 08/30/2013 - 2:12pm.

  8. Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy

    ... kinase pathways that induces mitotic arrest and apoptosis in neoplastic cells, while sparing normal cells. Our purpose is ...

    Research Article last updated 05/22/2014 - 10:23am.

  9. Immunological derangement in hypocellular myelodysplastic syndromes

    ... overexpression of FAS-L and of the TNF-related apoptosis -inducing ligand (TRAIL), underexpression of Flice-like inhibitory ...

    Research Article last updated 05/22/2014 - 9:53am.

  10. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... Subsequent to P53 activation, erythroid cell apoptosis and ineffective erythropoiesis occur. Other pathogenetic ...

    Research Article last updated 04/17/2014 - 11:29am.