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  1. Sicheng Wen, MD, PhD

    ... in vitro and in vivo by inhibition of DNA damage and apoptosis . In this study, we evaluated whether human MSC-EVs could reverse ...

    Grant Recipient last updated 01/05/2018 - 1:09pm.

  2. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... and by the occurrence of intramedullary apoptosis . During the past decade, the identification of key genetic and ...

    Research Article last updated 06/21/2017 - 11:10am.

  3. miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes

    ... the role of miR-378 in the proliferation and apoptosis of SKM-1 cells, an acute myeloid leukemia cell line established ... in SKM-1 cells interfered with proliferation via inducing apoptosis and G0/G1-phase cell cycle arrest, and suppressive effect of miR-378 ...

    Research Article last updated 11/02/2016 - 9:31am.

  4. A novel histone deacetylase inhibitor Chidamide induces G0/G1 arrest and apoptosis in myelodysplastic syndromes

    ... P21 protein expression. Meanwhile,it also induced cell apoptosis by down-regulating Bcl-2 and up-regulating cleaved Caspase-3 and ...

    Research Article last updated 11/02/2016 - 9:39am.

  5. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... and by the occurrence of intramedullary apoptosis . During the past decade, the identification of key genetic and ...

    Research Article last updated 04/29/2016 - 11:35am.

  6. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... responses can induce bone marrow failure due to apoptosis . Due to increased production of these cytokines and impaired ...

    Research Review last updated 05/02/2016 - 9:18am.

  7. Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS)

    ... administration may avoid high peak levels that can cause apoptosis . Furthermore, the low toxicity associated with low dose ...

    Clinical Trial last updated 04/29/2016 - 1:59pm.

  8. Pathogenesis of MDS: An overview of molecular and non-molecular aspects of the disease

    ... MDS is transcription of genes and cell cycle progression/ apoptosis , and genes involved in this pathway include RUNX1, TP53, and ... factors associated with the bone marrow microenvironment, apoptosis, cytokines, telomere length, and immune factors.  ...

    Research Review last updated 05/02/2016 - 9:14am.

  9. Anemia as the Main Manifestation of Myelodysplastic Syndromes

    ... to ineffective erythropoiesis, with a high degree of apoptosis of marrow erythroid progenitors. These progenitors show ...

    Research Article last updated 12/02/2015 - 8:45am.

  10. Nurse's Corner Summer 2015: Understanding the Etiology and Epidemiology of Myelodysplastic Syndromes

    ... that early in the disease leads to accelerated apoptosis and later to impaired differentiation and proliferation. ...

    Page last updated 07/27/2015 - 12:04pm.