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  1. Eltrombopag restores tri-lineage hematopoiesis in refractory severe aplastic anemia which can be sustained on discontinuation of drug

    ... About a quarter of patients with severe aplastic anemia (SAA) remain pancytopenic despite immunosuppressive therapy. We have ... is efficacious in a subset of patients with aplastic anemia refractory to IST, with frequent multilineage responses, and ...

    Research Article last updated 01/07/2014 - 12:22pm.

  2. Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia

    ... responses in 60-70% of patients with severe aplastic anemia . We performed a phase II study of rabbit anti-thymocyte globulin and cyclosporine as first-line therapy for severe aplastic anemia. DESIGN AND METHODS: Twenty patients with severe aplastic anemia treated ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Outcome of Pediatric Acquired Aplastic Anemia: A Developing World Experience.

    ... Outcome data of children with acquired aplastic anemia (AA) are lacking from the developing world. Here, we describe the ... Bone Marrow Diseases:  aplastic anemia ...

    Research Article last updated 07/09/2013 - 2:53pm.

  4. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... common is PNH appearing in patients with MDS or aplastic anemia ? The dual diagnosis of PNH and aplastic anemia is quite common. Perhaps half patients with PNH will have some sign of ...

    Interview last updated 05/14/2015 - 1:53pm.

  5. Moderate, Severe, and Very Severe Aplastic Anemia: How are treatment decisions made?

    ... Are treatments for each category aplastic anemia (moderate, severe, and very severe) also category-specific or are ... on a case-by-case basis? That’s correct—an aplastic anemia diagnosis is categorized in one of these three groups. The severe and ...

    Interview last updated 10/14/2015 - 12:47pm.

  6. Syngeneic transplantation in aplastic anemia: pretransplant conditioning and peripheral blood are associated with improved engraftment - an observational study on behalf of the Severe Aplastic Anemia and Pediatric Diseases Working Parties of the European

    ... 2013 Aplastic anemia is usually treated with immunosuppression or allogeneic transplant, ... analysis of all syngeneic transplants for aplastic anemia reported to the European Group for Blood and Marrow Transplantation. ...

    Research Article last updated 08/05/2013 - 9:44am.

  7. Evaluation of efficacy of alemtuzumab in 5 patients with aplastic anemia and/or myelodysplastic neoplasm

    ... Patients with aplastic anemia or hypoplastic myelodysplastic syndrome (MDS) may respond to ... responses to alemtuzumab in 5 patients with MDS or aplastic anemia (AA) evolving to MDS. Two patients with hypoplastic MDS (hMDS) showed a ...

    Research Article last updated 11/01/2016 - 1:56pm.

  8. Hematopoietic stem cell transplantation for acquired aplastic anemia

    ... marrow transplantation (BMT) for severe aplastic anemia (SAA), because of progress in optimization of the conditioning ... RECENT FINDINGS: Approximately one-third of aplastic anemia patients treated with immune suppressive therapy (IST) have acquired ...

    Research Article last updated 11/01/2016 - 1:55pm.

  9. Eltrombopag Added to IST Yields Encouraging Results

    ... and speed of recovery in seriously ill severe aplastic anemia patients.” – Danielle Townsley, MD How was eltrombopag originally considered to be tried in aplastic anemia? At first, we had only hoped eltrombopag would improve the ...

    Interview last updated 05/24/2017 - 7:44am.

  10. Eltrombopag for the treatment of aplastic anemia: current perspectives

    ... 2016 Aplastic anemia (AA) is a potential life-threatening hematopoietic stem cell (HSC) ... Bone Marrow Diseases:  aplastic anemia ...

    Research Article last updated 11/01/2016 - 2:01pm.