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  1. Multicenter study evaluating the impact of hypomethylating agents as bridging therapy to hematopoietic stem cell transplantation in myelodysplastic syndromes

    ... Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment ...

    Research Article last updated 04/16/2014 - 12:24pm.

  2. Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis.

    ... adult acquired aplastic anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Recent developments in bone marrow transplants

    ... Celgene) maintenance following autologous hematopoietic stem cell transplantation improved survival outcomes without increasing the ... with poor outcomes and shorter OS in patients undergoing allogeneic HSCT for myelodysplastic syndrome or acute myeloid leukemia. ...

    Article last updated 11/16/2016 - 2:56pm.

  4. Myelodysplastic syndromes: Contemporary review and how we treat

    ... syndromes (MDS) are a heterogeneous group of clonal stem cell disorders with an inherent tendency for leukemic transformation. ... lenalidomide for MDS with isolated del(5q). To date, allogeneic stem cell transplant (ASCT) remains the only treatment option ...

    Research Article last updated 04/29/2016 - 1:05pm.

  5. NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: report from the Committee on Disease-Specific Methods and Strategies for Monitoring Relapse following Allogenei

    ... has become the major cause of treatment failure after allogeneic stem cell transplantation. Outcome of patients with clinical relapse after ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Comparable outcomes between younger (⩽40 years) and older (>40 years) adult patients with severe aplastic anemia after HLA-matched sibling stem cell transplantation using fludarabine-based conditioning

    ... Allogeneic stem cell transplantation from HLA -matched siblings (MSD-SCT) for ...

    Research Article last updated 11/28/2016 - 9:28am.

  7. Personalized medicine for MDS

    ... be considered for a more intensive treatment, such as allogeneic stem cell transplant , earlier in the course of disease.  This personalized ...

    Research Review last updated 05/02/2016 - 9:44am.

  8. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... (OS) separately in the 2 arms at 1 year post-hematopoietic stem cell transplantation (HSCT). ... (MFI) > 1000 by solid phase immunoassay). Prior allogeneic stem cell transplant . Prior solid organ transplant. ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  9. Syngeneic transplantation in aplastic anemia: pretransplant conditioning and peripheral blood are associated with improved engraftment - an observational study on behalf of the Severe Aplastic Anemia and Pediatric Diseases Working Parties of the European

    ... anemia is usually treated with immunosuppression or allogeneic transplant, depending on patient and disease characteristics. ... and anti-thymocyte globulin as well as peripheral blood stem cells performed in later years. Ten year overall survival was 93% with ...

    Research Article last updated 08/05/2013 - 9:44am.

  10. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... Cyclophosphamide -based conditioning regimens and allogeneic hematopoietic stem cell transplantation (AlloHSCT) from matched related donors (MRD) has ...

    Research Article last updated 04/09/2014 - 9:11am.