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  1. Phase I, Dose Escalation Study of Decitabine

    ... that Decitabine delivered after allo-hematopoietic stem cell transplant (HSCT) in patients with leukemia will enhance disease control by the allogeneic immune system and lead to a longer disease free survival. The study ...

    Clinical Trial last updated 06/06/2016 - 9:44am.

  2. Incidence and Burden of the Myelodysplastic Syndromes

    ... may be considered for a clinical trial or allogeneic stem cell transplant if available.  This is a large unmet need in MDS.  ...

    Research Review last updated 05/02/2016 - 9:11am.

  3. Crenolanib in Combination With Sorafenib in Patients With Refractory or Relapsed Hematologic Malignancies

    ... salvage therapy, or has relapsed after hematopoietic stem cell transplant (HSCT). Participant disease tested positive for ... and If the participant received a prior allogeneic HSCT, at least 30 days have elapsed and there is no evidence of ...

    Clinical Trial last updated 06/06/2016 - 10:04am.

  4. Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

    ... undergoing myeloablative conditioning hematopoietic stem cell transplantation. Status:  ... Criteria:  Prior autologous or allogeneic hematopoietic stem cell transplant Karnofsky or Lansky ...

    Clinical Trial last updated 06/06/2016 - 1:36pm.

  5. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... a system called CliniMACS to remove Tcells from blood stem cells . Removing T-cells may help stop a side effect called ... by transplant for which CD34+ selected, T-cell depleted allogeneic hematopoietic stem cell transplantation is indicated such as: ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  6. Sirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HSCT

    ... with hematologic malignancies undergoing hematopoietic stem cell transplant (HSCT). Biological therapies, such as sirolimus and ... Intervention:  Procedure: Allogeneic Hematopoietic Stem Cell Transplantation Undergo HSCT Other ...

    Clinical Trial last updated 05/03/2016 - 11:35am.

  7. A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies

    ... (DLI) on day -6 and cluster of differentiation (CD)-34+ allogeneic peripheral blood stem cell transplantation (PBSCT) on day 0. GVHD PROPHYLAXIS: Beginning on ...

    Clinical Trial last updated 04/27/2016 - 1:56pm.

  8. Graft-vs-host-disease (GVHD): Signs, Symptoms, and Treatment

    ... Webinar An allogeneic stem cell transplant uses blood-forming cells ( stem cells ) donated by ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  9. RIC Transplant Using Haplo Donors

    ... will evaluate the safety and efficacy of a reduced intensity allogeneic HSCT from partially HLA -mismatched first-degree relatives utilizing PBSC as the stem cell source. The primary objective of the study is to estimate the ...

    Clinical Trial last updated 04/29/2016 - 10:52am.

  10. Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

    ... is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). This study aims to determine if any of three ...

    Clinical Trial last updated 06/06/2016 - 1:59pm.