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  1. Paroxysmal nocturnal hemoglobinuria

    ... Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exhibit seroreactivity against a human T-cell leukemia virus (HTLV) epitope, BA21. Aplastic anemia , ...

    Research Article last updated 07/30/2012 - 2:21pm.

  2. Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes

    ... Lastly, the capacity of MDS-MSCs to inhibit T lymphocyte activation and proliferation was impaired in vitro. These ...

    Research Article last updated 04/24/2012 - 2:10pm.

  3. A combination of fludarabine, half-dose cyclophosphamide, and anti-thymocyte globulin is an effective conditioning regimen before allogeneic stem cell transplantation for aplastic anemia

    ... Ashizawa M, Akahoshi Y, Nakano H, Ugai T, Wada H, Yamasaki R, Ishihara Y, Kawamura K, Sakamoto K, Sato M, Terasako K, ... . One became transfusion-independent after donor lymphocyte infusion, but continues to exhibit MC. The other regained ...

    Research Article last updated 03/06/2014 - 11:00am.

  4. In vivo effects of horse and rabbit antithymocyte globulin in patients with severe aplastic anemia

    ... much lower absolute number and relative frequency of CD4+ T cells, rabbit antithymocyte globulin induced higher frequencies of ... different pharmacokinetics and effects on neutrophils, lymphocyte subsets, and cytokine release. These differences may be related ...

    Research Article last updated 06/19/2014 - 12:42pm.

  5. The Evaluation of iron overload through hepcidin level and its related factors in myelodysplastic syndromes.

    ... an important role in the regulation of hepcidin expression. T- lymphocyte activation and Th polarization trend might participate in the ...

    Research Article last updated 05/14/2013 - 3:00pm.

  6. SAA Patient Dominique Hughes Contributes to NIH Research

    ... seen a biopsy that showed so much inflammation and didn’t know what to do at that point. Within a year I was seeing about five ... DiGeorge Syndrome, adenovirus, CVID, EBV virus, celiac, lymphocyte proliferation, and even HIV/AIDS. After about 7 or 8 months ...

    Patient Chronicle last updated 03/21/2017 - 11:32am.

  7. Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies

    ... effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. ... Therapeutic allogeneic lymphocytes Undergo donor lymphocyte infusion Other Names: Allogeneic Lymphocytes ALLOLYMPH Drug: ...

    Clinical Trial last updated 05/03/2016 - 10:51am.

  8. Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    ... This pilot phase II trial studies how well giving donor T cells after donor stem cell transplant works in treating patients ... Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. ...

    Clinical Trial last updated 05/03/2016 - 11:17am.

  9. Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer

    ... cells, and platelets. Giving an infusion of the donor's T cells (donor lymphocyte infusion) may help the patient's immune system see any remaining ...

    Clinical Trial last updated 04/29/2016 - 12:48pm.

  10. Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    ... undergo total body irradiation (TBI) followed by a donor lymphocyte infusion (DLI) on day -6. TRANSPLANT: Patients undergo ... Total-Body Irradiation Undergo TBI Biological: T Cell-Depleted Donor Lymphocyte Infusion Undergo DLI Drug: ...

    Clinical Trial last updated 04/27/2016 - 1:37pm.