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  1. Diagnosis and Treatment of Aplastic Anemia

    ... Author(s):  Peslak SA, Olson T, Babushok DV Original Publication Date:  ... that affects patients of all ages and is caused by lymphocyte destruction of early hematopoietic cells. Diagnosis of AA ...

    Research Article last updated 12/06/2017 - 8:45am.

  2. STAT3-mutations indicate the presence of subclinical T cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.

    ... Large granular lymphocyte leukemia (LGL) is often associated with immune cytopenias and ...

    Research Article last updated 07/29/2014 - 11:59am.

  3. Clinical Outcomes in Adult Patients with Aplastic Anemia- a single institution experience

    ... M, Pierce SA, Champlin R, Cortes J, Kantarjian H, Kadia T Original Publication Date:  ... By multivariate analysis, baseline platelet and lymphocyte count predicted for IST response at 3 and 6 months, ...

    Research Article last updated 09/13/2017 - 7:40am.

  4. A Marked Decrease in CD4-Positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-Associated Aplastic Anemia.

    ... Primary Author:  Ikeda T Author(s):  Ikeda T, Morimoto ... especially CD4 T-lymphocytopenia. Although the total lymphocyte counts rose as the patient recovered from hepatitis, this was ...

    Research Article last updated 04/26/2012 - 8:44am.

  5. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... characterized by development and expansion of self-reactive T cells. These T cells cause continuous destruction of hematopoietic stem ... AA was reproduced in animals, including mouse lymphocyte infusion models, which are used to study further etiology ...

    Research Article last updated 11/14/2013 - 11:18am.

  6. Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia

    ... by the evidence of 100 % donor hematopoiesis ; T lymphocyte subset counts also increased significantly after ...

    Research Article last updated 11/01/2016 - 1:59pm.

  7. Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia

    ... 2016 Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. ...

    Research Article last updated 04/29/2016 - 12:59pm.

  8. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... deficient progenitor cells, a novel T lymphocyte enrichment culture assay with proaerolysin selection to expand glycosylphosphatidylinositol-anchor deficient T lymphocytes , and PIG-A gene sequencing assays to identify and ...

    Research Article last updated 06/15/2012 - 1:48pm.

  9. Immune markers of disease severity and treatment response in pediatric acquired aplastic anemia

    ... with aplastic anemia (AA) and explore PNH-status, T-regulatory and NK-cell frequency as potential markers of clinical response. ... 2/6 PNH(neg) patients had a CR and 4/6 had a PR. Lymphocyte subset immunophenotyping revealed that T-regulatory cells ...

    Research Article last updated 07/31/2012 - 2:10pm.

  10. Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: results of a bone marrow failure consortium study.

    ... Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exhibit seroreactivity against a human T-cell leukemia virus (HTLV) epitope, BA21. Aplastic anemia , ...

    Research Article last updated 07/30/2012 - 2:51pm.