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  1. STAT3-mutations indicate the presence of subclinical T cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.

    ... Large granular lymphocyte leukemia (LGL) is often associated with immune cytopenias and ...

    Research Article last updated 07/29/2014 - 11:59am.

  2. A Marked Decrease in CD4-Positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-Associated Aplastic Anemia.

    ... Primary Author:  Ikeda T Author(s):  ... especially CD4 T-lymphocytopenia. Although the total lymphocyte counts rose as the patient recovered from hepatitis, this was ...

    Research Article last updated 04/26/2012 - 8:44am.

  3. Diagnosis and Treatment of Aplastic Anemia

    ... Author(s):  Peslak SA, Olson T, Babushok DV Original Publication ... that affects patients of all ages and is caused by lymphocyte destruction of early hematopoietic cells. Diagnosis of AA ...

    Research Article last updated 01/30/2018 - 10:53am.

  4. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... characterized by development and expansion of self-reactive T cells. These T cells cause continuous destruction of hematopoietic stem ... AA was reproduced in animals, including mouse lymphocyte infusion models, which are used to study further etiology ...

    Research Article last updated 11/14/2013 - 11:18am.

  5. Clinical Outcomes in Adult Patients with Aplastic Anemia- a single institution experience

    ... M, Pierce SA, Champlin R, Cortes J, Kantarjian H, Kadia T Original Publication Date:  ... By multivariate analysis, baseline platelet and lymphocyte count predicted for IST response at 3 and 6 months, ...

    Research Article last updated 09/13/2017 - 7:40am.

  6. SAA Patient Contributes to NIH Research

    ... seen a biopsy that showed so much inflammation and didn’t know what to do at that point. Within a year I was seeing about five ... DiGeorge Syndrome, adenovirus, CVID, EBV virus, celiac, lymphocyte proliferation, and even HIV/AIDS. After about 7 or 8 months ...

    Patient Chronicle last updated 04/26/2018 - 10:27am.

  7. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... deficient progenitor cells, a novel T lymphocyte enrichment culture assay with proaerolysin selection to expand glycosylphosphatidylinositol-anchor deficient T lymphocytes , and PIG-A gene sequencing assays to identify and ...

    Research Article last updated 06/15/2012 - 1:48pm.

  8. Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia

    ... Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. ...

    Research Article last updated 04/29/2016 - 12:59pm.

  9. Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia

    ... by the evidence of 100 % donor hematopoiesis ; T lymphocyte subset counts also increased significantly after ...

    Research Article last updated 11/01/2016 - 1:59pm.

  10. Immune markers of disease severity and treatment response in pediatric acquired aplastic anemia

    ... with aplastic anemia (AA) and explore PNH-status, T-regulatory and NK-cell frequency as potential markers of clinical response. ... 2/6 PNH(neg) patients had a CR and 4/6 had a PR. Lymphocyte subset immunophenotyping revealed that T-regulatory cells ...

    Research Article last updated 07/31/2012 - 2:10pm.