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  1. Resistance to Hypomethylating Agents in the Treatment of MDS

    ... applies mostly to higher-risk MDS patients, because we don’t usually treat lower-risk category patients upfront with these agents. ... effect by inhibiting protein synthesis. Both drugs enter the cell and require a special enzyme to cause phosphorylation that results in its ...

    Interview last updated 06/17/2014 - 9:15am.

  2. Veteran Patients

    ... The fact that an exposure is remote in time doesn’t mean it can’t contribute to MDS. A major  epidemiological study ... the 1960s or 1970s, that DNA injury in a bone marrow cell could have made it more likely that MDS would develop later on as a result ...

    Topic section last updated 03/25/2016 - 11:56am.

  3. What are the treatments for PNH?

    ... to do nothing but monitor your blood counts if they aren't too low and your symptoms aren't too bad. Supportive Care : ... , the destruction of red blood cells. Bone marrow/stem cell transplantation (BMT/SCT):  A procedure that replace your unhealthy ...

    FAQ last updated 03/15/2016 - 11:32pm.

  4. Aaron T. Gerds, MD, MS

    ... (CMML), with a special emphasis on allogeneic hematopoietic cell transplantation. Dr. Gerds is also an active member of the American ...

    Bio last updated 03/11/2016 - 1:41pm.

  5. What are the treatments for MDS?

    ... to do nothing but monitor you if your blood counts aren't too low and your symptoms aren't too bad. Supportive care : ... using drugs that kill abnormal cells. Bone marrow/stem cell transplantation (BMT/SCT): A procedure that replaces your unhealthy ...

    FAQ last updated 03/15/2016 - 11:31pm.

  6. Conferences, Webinars and Webcasts

    ... -Judy  I now know this disease shouldn’t stop me from living life as best I can. – Evelyn   Webinars & ...   Caregivers   Clinical Trials   Stem Cell Transplantation   Living Well   Nutrition   ...

    Page last updated 09/30/2014 - 11:50am.

  7. Interviews with the Experts MDS Genomics: Providing ‘Street View’ Directions of Disease

    ... for any study of chromosomes , genes, and DNA in a cell. “Genetics” is a more specific term that pertains to the study of just ... There are situations where patients and doctors aren’t completely sure if the patient has MDS or not. The patient may have low blood ...

    Interview last updated 09/23/2014 - 9:30am.

  8. MDS and MDS/MPN: Past, Present, and Future 2014 American Society of Hematology (ASH) Satellite Symposium Summary for Patients and Families

    ... advanced techniques to study genes and chromosomes don’t give enough information to find out what type of MDS or MDS/MPN a patient ... silenced genes). But some patients with MDS don’t respond to HMAs, and most patients who do respond eventually have a ... Can We Cure Them? The Role of Hematopoietic Stem Cell Transplantation in MDS/MPN.   Treatments for MDS/MPN are ...

    Page last updated 03/13/2015 - 5:00pm.

  9. Research Overview - Recent Past Progress and Projections for the Near-Term

    ... is that unlike solid tumors and leukemia, where there are cell lines that are propagated from the disease, we do not have reliable ... an enzyme called pyruvate dehydrogenase. This wasn’t just in MDS, but in all advanced hematologic malignancies. In this study, ...

    Interview last updated 02/10/2014 - 9:40am.

  10. Making the Most of Office Visits with Your Specialist

    ... one starts. It is ok for a patient to say “I don’t understand. Will you please rephrase or restate the diagnosis in a different ... acute myeloid leukemia (AML), and allogeneic hematopoietic cell transplant. Dr. Cogle leads a research laboratory that studies the biology ...

    Interview last updated 10/14/2015 - 9:05am.