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  1. Recurrent and Secondary MDS

    ... medical treatments, and even after an allogeneic stem cell transplant . So, I think of recurrent MDS to mean progression or ... recur. Once bone marrow and blood cancers recur, we don’t think of them as being curable by medical treatments. So when patients have ...

    Interview last updated 10/24/2012 - 1:12pm.

  2. Lenalidomide in lower-risk myelodysplastic syndromes with karyotypes other than deletion 5q and refractory to erythropoiesis-stimulating agents

    ... Sibon D, Cannas G, Baracco F, Prebet T, Vey N, Banos A, Besson C, Corm S, Blanc M, Slama B, Perrier H, Fenaux P, ... Lenalidomide (LEN) has been shown to yield red blood cell (RBC) transfusion independence in about 25% of lower risk ...

    Research Article last updated 04/24/2012 - 2:47pm.

  3. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

    ... Primary Author:  Graubert T Author(s):  ... Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress to chemotherapy -resistant secondary ...

    Research Article last updated 01/09/2012 - 2:17pm.

  4. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... JN, Padilla-Nash HM, Sloand EM, Wu CO, Scheinberg P, Ried T, Young NS Original Publication ... In cell and animal models, telomere erosion promotes chromosomal ...

    Research Article last updated 10/31/2011 - 2:58pm.

  5. Retrospective survey on the prevalence and outcome of prior autoimmune diseases in patients with aplastic anemia reported to the registry of the European group for blood and marrow transplantation.

    ... S, Marsh J, Tridello G, Rovò A, Maury S, Montante B, Masszi T, Van Lint MT, Afanasyev B, Iriondo Atienza A, Bierings M, Carbone C, Doubek ... therapy (IST), 8 patients underwent hematopoietic stem cell transplantation (HSCT) - 6 as first-line therapy and 2 after failure of ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Targeting immune dysregulation in myelodysplastic syndromes.

    ... cyclosporine have clonal expansions of cytotoxic CD8(+) T cells that suppress normal hematopoiesis, as well as expansion of CD4(+) helper T-cell subsets that promote and sustain autoimmunity. Immunosuppressive therapy ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Th17 immune responses contribute to the pathophysiology of aplastic anemia.

    ... de Latour RP, Visconte V, Takaku T, Wu C, Erie AJ, Sarcon AK, Desierto MJ, Scheinberg P, Keyvanfar K, Nunez O, ... higher platelet (P < .01) and total BM cell (P < .05) counts at day 10. Recipients that received anti-IL-17 treatment ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Duane Draper builds supportive community to help him with MDS and bone marrow transplant

    ... father of two grown children was asymptomatic and didn’t even realize that there was a problem with his health. Though he had been ... as well. Procrit shots increased his red blood cell production while he explored his options for treatment. A ...

    Patient Chronicle last updated 09/09/2014 - 10:02am.

  9. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... hemolysis .  In patients a with large PNH red cell population who need aplastic anemia treatment, one thing to do is give ... can be seen in PNH or aplastic anemia, but it doesn’t secure a diagnosis of MDS. ...

    Interview last updated 04/15/2015 - 9:39am.

  10. Special Issues for People with PNH

    ... things, it's a good idea to: Get a red blood cell count Get treatment for your anemia (blood transfusions or ... weigh the risks and benefits of getting a flu shot. Don’t forget to ask whether your family members and others in close contact with ...

    Page last updated 01/20/2015 - 4:59pm.