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  1. Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

    ... Inclusion Criteria:  Age, Graft Cell Dose and Graft HLA Criteria Subjects must be <70 years old. ... Study of Infusion of Umbilical Cord Blood Derived CD25+CD4+ T-Regulatory (Treg) Cells after Non-Myeloablative Cord\Blood Transplantation ...

    Clinical Trial last updated 05/02/2016 - 2:13pm.

  2. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... to remove Tcells from blood stem cells . Removing T-cells may help stop a side effect called Graft-Versus-Host Disease (GVHD) ... correctable by transplant for which CD34+ selected, T-cell depleted allogeneic hematopoietic stem cell transplantation is indicated ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  3. Resistance to Hypomethylating Agents in the Treatment of MDS

    ... applies mostly to higher-risk MDS patients, because we don’t usually treat lower-risk category patients upfront with these agents. ... effect by inhibiting protein synthesis. Both drugs enter the cell and require a special enzyme to cause phosphorylation that results in its ...

    Interview last updated 06/17/2014 - 9:15am.

  4. Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerou

    ... safety of nonmyeloablative conditioning and hematopoietic cell transplantation (HCT) from human leukocyte antigen ( HLA ... chimerism (> 5% cluster of differentiation [CD]3+ donor T-cell chimerism) in patients with nonmalignant inherited disorders. II. ...

    Clinical Trial last updated 04/26/2016 - 2:09pm.

  5. Intra-Osseous Co-Transplant of UCB and hMSC

    ... donor umbilical cord blood and mesenchymal stromal cell co-transplant in treating patients with hematologic malignancies. Giving ... Poor-risk cytogenetics (e.g., Philadelphia chromosome t(9;22)or 11q23 rearrangements) Presence of minimal disease by flow ...

    Clinical Trial last updated 05/02/2016 - 11:15am.

  6. KIR Favorable Mismatched Haplo Transplant and KIR Polymorphism in ALL/AML/MDS Allo-HCT Children

    ... (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). The relationship of KIR2DL1 polymorphisms to ... TCR alpha-beta-Biotin system Graft ex vivo depleted of T cell receptor (TCR) αβ+CD3+/CD19+ cells ...

    Clinical Trial last updated 04/29/2016 - 2:01pm.

  7. Sexuality and Intimacy

    ... (ATG ) (ALG) can cause fatigue and hypertension. White cell growth factors like G-CSF (Neupogen® or Filgrastim®) can cause ... and remember that problems before a serious illness don’t magically disappear during your illness. See a professional therapist to ...

    Page last updated 05/02/2016 - 10:09am.

  8. Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer

    ... Procedure: Allogeneic Hematopoietic Stem Cell Transplantation Undergo umbilical cord blood transplant Other Names: allogeneic stem cell transplantation HSC HSCT Drug: Cyclophosphamide Given IV Other ... T 586 Other: Laboratory Biomarker Analysis Correlative studies Drug: ...

    Clinical Trial last updated 04/28/2016 - 1:52pm.

  9. Abatacept Reduced Intensity for Non-Malignant Diseases (Aba NMD)

    ... Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only viable cure for children who ... from graft versus host disease (GVHD), driven by donor T cells recognizing and reacting against disparate host antigens. This trial is ...

    Clinical Trial last updated 04/27/2016 - 2:40pm.

  10. Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor

    ... Malignant conditions for which CD34+ selected, T-cell depleted allogeneic hematopoietic stem cell transplantation is indicated ...

    Clinical Trial last updated 04/29/2016 - 1:59pm.