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  1. Allo HSCT Using RIC for Hematological Diseases

    ... followed by a related or unrelated donor stem cell infusion. The primary objective is to evaluate rates of acute ... include but are not limited to cytogenetics demonstrating t(9;22), t (1:19), t(4;11), other MLL rearrangements, hypodiploidy, or IKZF1 ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  2. Interviews with the Experts Comorbidities: When Other Medical Conditions Affect MDS Treatment

    ... cases this particular comorbid condition can even help: red cell growth factors like darbepoetin (Aranesp®) or epoetin (Procrit®) can ... So in many cases, patients with serious comorbidities aren’t eligible to participate in clinical trials. But that restrictive clinical ...

    Interview last updated 11/17/2014 - 9:31am.

  3. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... hemolysis .  In patients a with large PNH red cell population who need aplastic anemia treatment, one thing to do is give ... can be seen in PNH or aplastic anemia, but it doesn’t secure a diagnosis of MDS. Interviewee:  ...

    Interview last updated 04/15/2015 - 9:39am.

  4. Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer

    ... the side effects and best dose of donor natural killer (NK) cell therapy and to see how well it works when given together with ... cells, and platelets. Giving an infusion of the donor's T cells (donor lymphocyte infusion) may help the patient's immune ...

    Clinical Trial last updated 04/29/2016 - 12:48pm.

  5. Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

    ... Inclusion Criteria:  Age, Graft Cell Dose and Graft HLA Criteria Subjects must be <70 years old. ... Study of Infusion of Umbilical Cord Blood Derived CD25+CD4+ T-Regulatory (Treg) Cells after Non-Myeloablative Cord\Blood Transplantation ...

    Clinical Trial last updated 05/02/2016 - 2:13pm.

  6. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... to remove Tcells from blood stem cells . Removing T-cells may help stop a side effect called Graft-Versus-Host Disease (GVHD) ... correctable by transplant for which CD34+ selected, T-cell depleted allogeneic hematopoietic stem cell transplantation is indicated ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.

  7. Sirolimus, Idarubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

    ... of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy , such as idarubicin and ... Subjects with APL - FAB M3 (t(15;17)(q22;q21)[PML-RAR] are not eligible Subjects must not have received ...

    Clinical Trial last updated 06/13/2016 - 3:24pm.

  8. Fludarabine/Clofarabine/Busulfan Combined With SAHA in Acute Leukemia

    ... course of induction and with favorable cytogenetics [t(8;21, inv 16, or t(15;17)] and/or molecular profile (NPM1). Prior ... Acid MSK-390 Zolinza Procedure: Stem Cell Infusion (SCT) Stem cell infusion on Day 0. Drug: ...

    Clinical Trial last updated 06/06/2016 - 11:07am.

  9. Aplastic Anemia: Why Treatments Work and Why They Don't

    ... Immunosuppressive therapy and stem cell transplantation are the main treatment options for aplastic anemia ... Aplastic Anemia: Why Treatments Work and Why They Don't/Aplastic Anemia: Why Treatments Work and Why They Don't ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  10. Aplastic Anemia: Why Treatments Work and Why They Don't

    ... Immunosuppressive therapy and stem cell transplantation are the main treatment options for aplastic anemia ... Aplastic Anemia: Why Treatments Work and Why They Don't ...

    LMS Item last updated 06/10/2016 - 1:24pm.