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  1. Myelofibrosis (MF)

    ... and chronic inflammation. If the marrow is scarred, it can’t produce blood cells correctly or perform its normal functions. As a result, ... myelofibrosis than younger people. Having another blood cell disorder, like essential thrombocythemia or polycythemia vera, as these ...

    Topic section last updated 07/07/2016 - 3:16pm.

  2. Biting into the Elephant

    ... low. They told us there was something wrong, but they didn’t know what it was. Referring us to a hematologist / oncologist , ... azacitidine (Vidaza®) treatment followed by a stem cell transplant . I received the gift of life from my brother Neal on ...

    Patient Chronicle last updated 06/27/2016 - 2:22pm.

  3. Interviews with the Experts Comorbidities: When Other Medical Conditions Affect MDS Treatment

    ... cases this particular comorbid condition can even help: red cell growth factors like darbepoetin (Aranesp®) or epoetin (Procrit®) can ... So in many cases, patients with serious comorbidities aren’t eligible to participate in clinical trials. But that restrictive clinical ...

    Interview last updated 11/17/2014 - 9:31am.

  4. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... hemolysis .  In patients a with large PNH red cell population who need aplastic anemia treatment, one thing to do is give ... can be seen in PNH or aplastic anemia, but it doesn’t secure a diagnosis of MDS. ...

    Interview last updated 04/15/2015 - 9:39am.

  5. Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

    ... understood, but incomplete elimination of auto-reactive T cells and insufficient stem cell reserve are both possible. Furthermore, 10-15% of SAA patients treated ...

    Clinical Trial last updated 04/25/2016 - 2:47pm.

  6. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... strategies to augment the well documented effect of NK cell alloreactivity seen in HLA -mismatched transplantation. These ... receive a nonmyeloablative haploidentical transplant using a T-cell replete allograft and post-transplant cyclophosphamide as ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  7. Allo HSCT Using RIC for Hematological Diseases

    ... followed by a related or unrelated donor stem cell infusion. The primary objective is to evaluate rates of acute ... include but are not limited to cytogenetics demonstrating t(9;22), t (1:19), t(4;11), other MLL rearrangements, hypodiploidy, or IKZF1 ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  8. Heather Putney’s Trials (and Travels) with Aplastic Anemia

    ... and a bladder infection, telling my reflection, “I don’t know how much more I can take.” And then you have the mirrors you see in ... been poisoned by medicine designed to kill every last stem cell. It has been deprived of sleep and nourishment. It has been injected with ...

    Patient Chronicle last updated 08/15/2016 - 8:42am.

  9. Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer

    ... the side effects and best dose of donor natural killer (NK) cell therapy and to see how well it works when given together with ... cells, and platelets. Giving an infusion of the donor's T cells (donor lymphocyte infusion) may help the patient's immune ...

    Clinical Trial last updated 04/29/2016 - 12:48pm.

  10. Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

    ... Inclusion Criteria:  Age, Graft Cell Dose and Graft HLA Criteria Subjects must be <70 years old. ... Study of Infusion of Umbilical Cord Blood Derived CD25+CD4+ T-Regulatory (Treg) Cells after Non-Myeloablative Cord\Blood Transplantation ...

    Clinical Trial last updated 05/02/2016 - 2:13pm.