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  1. Biting into the Elephant

    ... low. They told us there was something wrong, but they didn’t know what it was. Referring us to a hematologist / oncologist , ... azacitidine (Vidaza®) treatment followed by a stem cell transplant . I received the gift of life from my brother Neal on ...

    Patient Chronicle last updated 06/27/2016 - 2:22pm.

  2. Heather Putney’s Trials (and Travels) with Aplastic Anemia

    ... and a bladder infection, telling my reflection, “I don’t know how much more I can take.” And then you have the mirrors you see in ... been poisoned by medicine designed to kill every last stem cell. It has been deprived of sleep and nourishment. It has been injected with ...

    Patient Chronicle last updated 08/15/2016 - 8:42am.

  3. Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

    ... understood, but incomplete elimination of auto-reactive T cells and insufficient stem cell reserve are both possible. Furthermore, 10-15% of SAA patients treated ...

    Clinical Trial last updated 04/25/2016 - 2:47pm.

  4. North American Pediatric Aplastic Anemia Consortium Symposium

    ... to show mild dysplasia and patchy areas of red blood cell , or erythroid, precursors. However, in the absence of an MDS defining ... graft rejection, which is problematic for patients who don’t respond to IST. As donor matching and supportive care within hematopoietic ...

    Page last updated 10/31/2013 - 4:06pm.

  5. Research Retrospective for AA&MDSIF 30th Anniversary - Dr. Neal Young

    ... readily available to most patients, changes in red blood cell transfusion methods have decreased the problem of alloimmunization, ... of the underlying pathophysiology , we really don’t’ understand it in detail. So, empirically, horse ATG remains our best ...

    Interview last updated 05/08/2013 - 2:51pm.

  6. Eltrombopag: Recent Discoveries on Potential New Applications for Aplastic Anemia

    ... in some patients, but also improve white and red blood cell counts. This was a surprising finding, as the drug was really ... trials for aplastic anemia? Originally we weren't that hopeful that eltrombopag would be useful in aplastic anemia, because the ...

    Interview last updated 02/14/2014 - 2:01pm.

  7. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... strategies to augment the well documented effect of NK cell alloreactivity seen in HLA -mismatched transplantation. These ... receive a nonmyeloablative haploidentical transplant using a T-cell replete allograft and post-transplant cyclophosphamide as ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  8. Understanding Prognosis in MDS

    ... may suggest a more risky therapy, such as a stem cell transplant , be tried. A better prognosis that indicates a longer life ... and decitabine (Dacogen®)—and IPSS doesn’t take the effect of these into account. Another drawback is that it is not ...

    Interview last updated 05/02/2012 - 4:36pm.

  9. Allo HSCT Using RIC for Hematological Diseases

    ... followed by a related or unrelated donor stem cell infusion. The primary objective is to evaluate rates of acute ... include but are not limited to cytogenetics demonstrating t(9;22), t (1:19), t(4;11), other MLL rearrangements, hypodiploidy, or IKZF1 ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  10. Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer

    ... the side effects and best dose of donor natural killer (NK) cell therapy and to see how well it works when given together with ... cells, and platelets. Giving an infusion of the donor's T cells (donor lymphocyte infusion) may help the patient's immune ...

    Clinical Trial last updated 04/29/2016 - 12:48pm.