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  1. Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Sy

    ... monoclonal antibody together with donor stem cell transplant , fludarabine phosphate, cyclophosphamide, mycophenolate ... monohydrate CTX CYCLO-cell Cycloblastin Cycloblastine Cyclophospham Cyclophosphamid ... T 586 Radiation: Iodine I 131 Monoclonal Antibody BC8 Given IV (dosimetry ...

    Clinical Trial last updated 04/28/2016 - 1:01pm.

  2. Infections in myelodysplastic syndromes: a review

    ... transiently worsening the pre-existing low white blood cell (WBC) counts. However, this increased risk of infections with ... infections, several other immune defects involving B cells, T cells and NK cells have been described. A wide spectrum of infections ...

    Research Review last updated 05/02/2016 - 9:28am.

  3. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... with paroxysmal nocturnal hemoglobinuria (PNH) don’t have two important proteins, CD55 and CD59, that normally protect red blood ... examined the effects of C1 INH on premature red blood cell destruction in blood samples from 5 patients with PNH and 3 healthy ...

    Research Review last updated 05/02/2016 - 9:21am.

  4. Transplantation Update

    ... toxicity from the regimens used to prepare patients for stem cell transplants regardless of who the donor is or the source of stem cells ... The results showed that this can work, but we can’t completely omit cyclophosphamide because there was failure of engraftment ...

    Interview last updated 05/14/2015 - 2:42pm.

  5. Diagnosis

    ... uses a number of methods to measure how many of each blood cell type are in your blood sample. If the CBC shows a low number of red blood ... that are not normal. These abnormal looking cells don’t work right, and this can lead to anemia. ...

    Topic section last updated 04/19/2016 - 3:35pm.

  6. Role of microRNAs in Aplastic Anemia

    ... M.D.   Abstract 2940: Altered microRNAs in T cells from Patients with Acquired Aplastic Anemia MicroRNAs ... from healthy people and from patients with MDS or sickle cell disease. Key findings: miRNAs were downregulated, meaning that ...

    Research Review last updated 05/02/2016 - 9:15am.

  7. Myelodysplastic Syndromes and autoimmune disorders: Cause or consequence?

    ... cytopenias in MDS patients. For instance, deregulated T cell immunity which leads to downstream inflammatory responses can induce ...

    Research Review last updated 05/02/2016 - 9:18am.

  8. AA&MDSIF announces PNH grant awards

    ... hemolytic anemia that results from the loss of cell surface complement regulators. These patients have hemolytic anemia, risk ... functional effects of the PIG-A mutation in CD34+ cells and T- cells shared by PNH, MDS and aplastic anemia patients. The goal is to ...

    Article last updated 12/14/2016 - 11:41am.

  9. Disease Won't Run My Life

    ... Jersey and I walked in while he parked the car.  I didn’t know I wouldn’t be leaving for five more days. Once I explained my ... but my very low blood counts continued for all three cell lines. The “aplastic crisis” morphed into severe aplastic anemia which ...

    Patient Chronicle last updated 05/10/2016 - 3:36pm.

  10. Immunosuppressive Therapy

    ... works by killing specific cells in your immune system called T-lymphocytes — the cells that are attacking bone marrow stem cells ... prevents T-lymphocytes, a type of white blood cell , from becoming active. Once the T-lymphocytes are turned off by the ...

    Topic section last updated 04/01/2016 - 2:24pm.