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  1. Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

    ... Background: - In allogeneic stem cell transplantation (SCT), stem cells are taken from a donor and given ... defined as complex karyotype (> 3 abnormalities); inv(3) or t(3;3); t(6;9); t(6;11); monosomy 7 ; trisomy 8, alone or with an ...

    Clinical Trial last updated 04/29/2016 - 1:00pm.

  2. Polymorphism of the complement receptor 1 gene correlates with hematological response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

    ... Primary Author:  Rondelli T Author(s):  Rondelli T, ... response is variable and some patients remain red blood cell transfusion -dependent. In 72 patients with hemolytic Paroxysmal ...

    Research Article last updated 09/26/2013 - 3:28pm.

  3. NHLBI profiles a member of the Foundation’s patient community.

    ... have no apparent origin. Emily first found out her blood cell counts were abnormally low when she was being treated for rheumatoid ... a weeklong, painful procedure, and unfortunately, it didn’t work,” Emily said. “My blood cell counts continued to drop.” Making ...

    Article last updated 06/13/2016 - 1:51pm.

  4. Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies

    ... (GVHD) after nonmyeloablative peripheral blood stem cell (PBSC) transplant in patients with hematological malignancies. Giving low ... T 586 Other: Laboratory Biomarker Analysis Correlative studies Drug: ... Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation Undergo nonmyeloablative allogeneic PBSC ...

    Clinical Trial last updated 05/03/2016 - 9:44am.

  5. The Effect of Decitabine Dose Modification and Myelosuppression on Response and Survival in Patients With Myelodysplastic Syndromes

    ... G, Cornelison AM, Cortes JE, Ravandi F, Daver N, Kadia T, Teng A, Kantarjian H Original Publication Date:  ... with MDS conducted Cox regression analyses of red blood cell or platelet dependence, myelosuppression, dose modification, ...

    Research Article last updated 06/02/2014 - 11:03am.

  6. Eltrombopag Added to IST Yields Encouraging Results

    ... cohort. We call this an adaptive study design – it wasn’t all envisioned at the start. Were there any other general aims as the ... would respond to the treatment. Telomeres get shorter with cell divisions and may represent how exhausted the bone marrow is prior ...

    Interview last updated 05/24/2017 - 7:44am.

  7. A Comparison of Outcomes for Cord Blood Transplant and Unrelated Bone Marrow Transplant in Adult Aplastic Anemia

    ... Kuwatsuka Y, Kanda J, Yamazaki H, Mori T, Miyamura K, Kako S, Uchida N, Ohashi K, Ozawa Y, Takahashi Y, Kato C, Iwato ... registry data of the Japan Society for Hematopoietic Cell Transplantation and compared results of UCBT (n = 69) to 8/8-matched ...

    Research Article last updated 08/15/2016 - 1:06pm.

  8. Prospective assessment of effects on iron-overload parameters of deferasirox therapy in patients with myelodysplastic syndromes.

    ... Greenberg PL, Koller CA, Cabantchik ZI, Warsi G, Glynos T, Paley C, Schiffer C Original Publication Date:  ... 52 weeks of therapy despite ongoing receipt of red blood cell transfusions. Bone Marrow Diseases:  ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

    ... N, Giricz O, Sukrithan V, Nwankwo G, Shahnaz S, Bhagat T, Bhattacharyya S, Assal A, Shastri A, Gordon-Mitchell S, Pellagatti A, ... transcriptomic signature similar to known MDS/AML stem-like cell profiles. In seeking a small molecule inhibitor of this pathway, we ...

    Research Article last updated 07/18/2016 - 11:12am.

  10. 7-year-old Little Mermaid fan gets her BMT

    ... hurting," said Yasmin's aunt, Belen Jackson. "And she couldn't move. So this, seeing her here, it's great." Yasmin was surrounded by a ... continue weekly visits to the hospital to monitor Yasmin's cell engraftment level. Right now, it's at 100 percent. This means her ...

    Article last updated 06/14/2016 - 11:52am.