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  1. Novel strategies to prevent relapse after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia and myelodysplastic syndromes

    ... neoplasms after allogeneic haematopoietic stem cell transplantation (HSCT) remains one of the leading causes of death. ... namely natural killer (NK) cell enrichment and adoptive T cell transfer, are emerging. Targeted therapies including vaccinations, ...

    Research Article last updated 03/02/2015 - 1:25pm.

  2. Foundation Update - October 2017

    ... sister/caregiver Isabella, several weeks after his stem cell transplant for severe aplastic anemia . Here's what each had to ... and Treatment; October 23, 2017; 1:00 PM EDT Don't miss these archived webinars >What is Peripheral Neuropathy? Understanding ...

    Article last updated 11/30/2017 - 2:30pm.

  3. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.

    ... phagocytosis, the latter due to the up-regulation of cell surface calreticulin, a prophagocytic marker. Blocking calreticulin on low ... for the cytopenias, and that up-regulation of the "don't eat me" signal CD47 on MDS myeloid progenitors is an important transition ...

    Research Article last updated 03/05/2013 - 9:20am.

  4. Emerging Therapeutics for the Control of Chronic Graft-versus-Host Disease

    ... mortality and morbidity after allogeneic hematopoietic stem cell transplantation (SCT). In parallel with an increased use of ... facets of adaptive and innate immunity, including B cells, T cells, and macrophages and their interactions with target tissue. ...

    Research Article last updated 01/04/2018 - 2:44pm.

  5. Jill Minden’s Encounter with Aplastic Anemia

    ... low. I had no idea what that meant at the time, and wasn’t overly alarmed. Two weeks and two different hospitals later, I was diagnosed ... T.J., had turned into hospitals, weekly red blood cell and platelet transfusions, and lots of fear. I was treated at ...

    Patient Chronicle last updated 09/05/2017 - 10:57am.

  6. Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

    ... human leukocyte antigen ( HLA )–restricted T cell immunity, with earlier studies favoring HLA class II-mediated ...

    Research Article last updated 10/23/2017 - 10:56am.

  7. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... phase I trial studies the side effects of donor stem cell transplant in treating patients with high risk acute myeloid leukemia. ... (with > 3 cytogenetic abnormalities), del (7q, -5, -7), t(9,22), 11q(23) or high risk mutations by FISH eg MLL, FLT-3 + ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.

  8. Marrow protein may be key to SCT success

    ... Bone Marrow Protein May Be Target for Improving Stem Cell Transplants Article ... and neutrophils, rather than lymphocytes, such as T cells and B cells. In bone marrow transplant experiments, the ...

    Article last updated 08/29/2017 - 11:18am.

  9. Allogeneic stem cell transplantation using alemtuzumab-containing regimens in severe aplastic anemia.

    ... engraftment after allogeneic haemopoietic stem cell transplant (HSCT). Its associated low incidence of GVHD makes it an ... tolerance post-HSCT with the findings of stable mixed T cell chimerism with full donor myeloid chimerism and the absence of ...

    Research Article last updated 06/20/2013 - 10:30am.

  10. Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies (AB-CliniMACs)

    ... is a single arm pilot study for patients using α/β T cell -depleted PSCT in with alternative donor sources with hematologic ...

    Clinical Trial last updated 06/06/2016 - 3:10pm.