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  1. Rational Management Approach To Pure Red Cell Aplasia

    ... 6, 2017 Pure red cell aplasia is an orphan disease without rationally established standard ... There is overlap between idiopathic cases and those with T-large granular lymphocytic leukemia, hypogammaglobulinemia, and low-grade ...

    Research Article last updated 12/14/2017 - 10:12am.

  2. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... How did the idea to study a particular type of stem cell transplant originate? The idea for the study in question is an ... are at increased risk of graft rejection. The lower T cell content and stem cell content in cord blood units likely accounted ...

    Interview last updated 10/04/2017 - 1:36pm.

  3. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... PNH is closely related to aplastic anemia , in which T cells mediate destruction of BM. To identify aberrant molecular mechanisms ... BM, we applied RNA-seq to examine the transcriptome of T cell subsets (CD4+ naive, CD4+ memory, CD8+ naive, and CD8+ memory) from ...

    Research Article last updated 07/27/2017 - 2:06pm.

  4. Luspatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes (PACE-MDS): a multicentre, open-label phase 2 dose-finding study with long-term extension study

    ... U, Götze KS, Kiewe P, Mayer K, Chromik J, Radsak M, Wolff T, Zhang X, Laadem A, Sherman ML, Attie KM, Giagounidis A ... chronic myelomonocytic leukaemia ( white blood cell count <13 000/μL), and had anaemia with or without red blood ...

    Research Article last updated 09/18/2017 - 1:38pm.

  5. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... PNH is closely related to aplastic anemia , in which T cells mediate destruction of BM. To identify aberrant molecular mechanisms ... BM, we applied RNA-seq to examine the transcriptome of T cell subsets (CD4+ naive, CD4+ memory, CD8+ naive, and CD8+ memory) from ...

    Research Article last updated 07/11/2017 - 10:43am.

  6. Explaining SCT vs. Cellular Therapies

    ... Article Link:  Stem Cell Transplants and Cellular Therapies: What’s the Difference? ... system cells, including chimeric-antigen receptor (CAR) T cells, are another form of cellular therapy that involves modifying the ...

    Article last updated 09/08/2017 - 12:41pm.

  7. Foundation Update - October 2017

    ... sister/caregiver Isabella, several weeks after his stem cell transplant for severe aplastic anemia . Here's what each had to ... and Treatment; October 23, 2017; 1:00 PM EDT Don't miss these archived webinars >What is Peripheral Neuropathy? Understanding ...

    Article last updated 11/30/2017 - 2:30pm.

  8. Updates from John and Isabella!

    ... sister/caregiver Isabella, several weeks after his stem cell transplant for severe aplastic anemia . Here's what each had to ... and he’s up to about 6 laps right now.  So if we don’t’ make that goal, he would have to remain here longer. But becoming ...

    Patient Chronicle last updated 10/12/2017 - 1:01pm.

  9. Pure Red Cell Aplasia (PRCA)

    Pure Red Cell Aplasia (PRCA) ... to increase red blood cell levels. Patients who don’t respond to other treatments may need to rely on transfusions on an ongoing ... cause of the PRCA is immunological and the patient hasn’t responded to corticosteroids. Drug therapies include cyclophosphamide ...

    Topic section last updated 07/07/2016 - 3:14pm.

  10. Novel strategies to prevent relapse after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia and myelodysplastic syndromes

    ... neoplasms after allogeneic haematopoietic stem cell transplantation (HSCT) remains one of the leading causes of death. ... namely natural killer (NK) cell enrichment and adoptive T cell transfer, are emerging. Targeted therapies including vaccinations, ...

    Research Article last updated 03/02/2015 - 1:25pm.