Search | Page 2 | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... stem cells due to a mutation in the PIG-A gene leading to a deficiency of GPI-anchored proteins. Lack of two specific ...

    Research Article last updated 11/05/2013 - 12:37pm.

  2. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... cell (HSC) that acquires a somatic mutation in a gene called phosphatidylinositol glycan anchor biosynthesis, class A (PIG-A). The PIG-A gene is required for the first step in ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... of an inactivating mutation of the X-linked gene PIG-A, are deficient in glycosylphosphatidylinositol (GPI)-linked ...

    Research Article last updated 06/07/2016 - 10:56am.

  4. PNH: Causes

    ... PNH occurs because of a change ( mutation ) in the PIG-A gene of a single stem cell in the bone marrow . This gene allows a ...

    Page last updated 06/29/2015 - 8:44am.

  5. Interviews with the Experts: The Complement System in PNH

    ... in PNH this GPI anchor is missing because of a mutation in a gene called PIG-A. This defective gene leads to cause the cell’s inability to form this ...

    Interview last updated 08/31/2016 - 8:39am.

  6. The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance

    ... a monogenic disorder due to acquisition of mutations in the gene encoding PIGA, which is required for glycosylphosphatidylinositol (GPI) ...

    Research Article last updated 10/02/2014 - 8:29am.

  7. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... disease that results from somatic mutations in the gene encoding PIGA, which is required for biosynthesis of ...

    Research Article last updated 10/02/2014 - 8:24am.

  8. Paroxysmal nocturnal hemoglobinuria

    ... is almost always due to somatic mutations in PIGA, a gene involved in the first step of GPI anchor biosynthesis; however, ...

    Research Article last updated 10/02/2014 - 8:35am.

  9. Hideki Makishima, MD, PhD

    ... PNH is a disease in which a mutation in the gene called PIG-A is acquired in the stem cells (mother cells of all blood cells) ...

    Grant Recipient last updated 07/07/2014 - 11:46am.

  10. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... mutations in the Phosphatidylinositol Glycan class A (PIG-A) gene in the hematopoietic stem cells (HSC) of patients. The presence of ...

    Research Article last updated 10/22/2013 - 3:44pm.