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  1. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... mutation in the phosphatidylinositol glycan class A gene ( PIG-A ) on the X chromosome, which blocks synthesis of the glycolipid moiety ...

    Research Article last updated 07/27/2017 - 2:06pm.

  2. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... mutation in the phosphatidylinositol glycan class A gene (PIG-A) on the X chromosome, which blocks synthesis of the glycolipid moiety and ...

    Research Article last updated 07/11/2017 - 10:43am.

  3. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... from a multipotent hematopoietic stem cell acquiring a PIG-A mutation . Many patients with aplastic anemia and ... deficient T lymphocytes , and PIG-A gene sequencing assays to identify and analyze PIG-A mutations in ...

    Research Article last updated 06/15/2012 - 1:48pm.

  4. The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria

    Journal Title:  Am J Hum Genet Primary Author:  Johnston JJ Author(s):  Johns...

    Research Article last updated 07/30/2012 - 2:24pm.

  5. Local TV covers AAMDSIF Peer Support Networker

    ... blood cells to early. Red blood cells are missing the PIG-A gene that allows glycosyl-phosphatidylinositol (GPI) to help certain ...

    Article last updated 11/28/2016 - 3:21pm.

  6. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... the cells from being attacked by the complement system. The gene in charge of making this protective shield is called PIG-A. ...

    Page last updated 02/27/2017 - 7:37am.

  7. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... disorder resulting from somatic mutation in the PIG-A gene leading to a deficiency of the membrane-anchoring molecule ...

    Research Article last updated 09/13/2016 - 1:53pm.

  8. Pathogenesis of paroxysmal nocturnal hemoglobinuria

    ... deficiency caused by somatic mutation of the PIGA gene in one or several hematopoietic stem cells . Recently, PNH caused by somatic mutation of one allele of the PIGT gene in combination with a germline mutation of the other allele was reported, ...

    Research Article last updated 11/02/2016 - 2:52pm.

  9. Paroxysmal Nocturnal Hemoglobinuria: From Bench to Bed

    ... in the X-linked phosphatidylinositol glycan class A (PIGA) gene that results in deficiency of the glycosylphosphatidylinositol anchor ...

    Research Article last updated 11/28/2016 - 11:40am.

  10. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... stem cells due to a mutation in the PIG-A gene leading to a deficiency of GPI-anchored proteins. Lack of two specific ...

    Research Article last updated 11/05/2013 - 12:37pm.