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  1. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... the cells from being attacked by the complement system. The gene in charge of making this protective shield is called PIG-A. ...

    Page last updated 09/30/2017 - 11:34am.

  2. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... mutation in the phosphatidylinositol glycan class A gene ( PIG-A ) on the X chromosome, which blocks synthesis of the glycolipid moiety ...

    Research Article last updated 07/27/2017 - 2:06pm.

  3. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... mutation in the phosphatidylinositol glycan class A gene (PIG-A) on the X chromosome, which blocks synthesis of the glycolipid moiety and ...

    Research Article last updated 07/11/2017 - 10:43am.

  4. AA&MDSIF announces PNH grant awards

    ... . PNH is caused by a somatic mutation in the PIG-A gene , which is responsible for a cellular protein deficiency that is ...

    Article last updated 12/14/2016 - 11:41am.

  5. Local TV covers AAMDSIF Peer Support Networker

    ... blood cells to early. Red blood cells are missing the PIG-A gene that allows glycosyl-phosphatidylinositol (GPI) to help certain ...

    Article last updated 11/28/2016 - 3:21pm.

  6. Paroxysmal Nocturnal Hemoglobinuria: From Bench to Bed

    ... in the X-linked phosphatidylinositol glycan class A (PIGA) gene that results in deficiency of the glycosylphosphatidylinositol anchor ...

    Research Article last updated 11/28/2016 - 11:40am.

  7. David Araten, MD

    ... has as its feature the presence of a mutation in a gene called PIG-A. Different patients have different types of mutations in this gene, but ...

    Grant Recipient last updated 11/30/2016 - 10:51am.

  8. Pathogenesis of paroxysmal nocturnal hemoglobinuria

    ... deficiency caused by somatic mutation of the PIGA gene in one or several hematopoietic stem cells . Recently, PNH caused by somatic mutation of one allele of the PIGT gene in combination with a germline mutation of the other allele was reported, ...

    Research Article last updated 11/02/2016 - 2:52pm.

  9. Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

    ... disorder resulting from somatic mutation in the PIG-A gene leading to a deficiency of the membrane-anchoring molecule ...

    Research Article last updated 09/13/2016 - 1:53pm.

  10. Interviews with the Experts: The Complement System in PNH

    ... in PNH this GPI anchor is missing because of a mutation in a gene called PIG-A. This defective gene leads to cause the cell’s inability to form this ...

    Interview last updated 08/31/2016 - 8:39am.