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  1. Safety and Efficacy of Two Doses of ATIR101, a T-lymphocyte Enriched Leukocyte Preparation Depleted of Host Alloreactive T-cells, in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor

    ... family donor with 2 to 3 mismatches at the HLA -A, -B and/or -DR loci of the unshared haplotype Male or female, age ... ATIR101 (e.g., dimethyl sulfoxide) Known presence of HLA antibodies against the non-shared donor haplotype Any other ...

    Clinical Trial last updated 04/29/2016 - 12:25pm.

  2. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... best candidates.   For young patients lacking an HLA -matched sibling donor, immunosuppressive therapy (IST) with ... deciding between IST versus transplant is how quickly an HLA-matched donor can be found and cleared for collection. Donor availability ...

    Interview last updated 11/28/2016 - 2:58pm.

  3. Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

    ... Age, Graft Cell Dose and Graft HLA Criteria Subjects must be <70 years old. Subjects ages ≥ 70 and ... (HCT-CI) score ≤ 2. The UCB graft is matched at 4-6 HLA-A, B, DRB1 antigens with the recipient. Patients co-enrolled in ...

    Clinical Trial last updated 05/02/2016 - 2:13pm.

  4. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... undergo allogeneic stem cell transplantation from an HLA identical sibling or match unrelated donor using the identical ... inclusive), and weight > 18kg     Availability of HLA identical or single HLA locus mismatched family donor or 10/10 matched ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.

  5. Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    ... Molecular based human leukocyte antigen ( HLA ) typing will be performed for the HLA-A, -B, -Cw, -DRB1 and -DQB1 loci to the resolution adequate to establish ...

    Clinical Trial last updated 04/29/2016 - 3:26pm.

  6. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... failed HCT An human leukocyte antigen ( HLA )-identical related or an HLA-matched unrelated donor (Fred Hutchinson Cancer Research Center ...

    Clinical Trial last updated 04/28/2016 - 2:45pm.

  7. StemRegenin-1 Expanded vs Unexpanded UCB for High Risk Heme Malignancies

    ... Must have a partially HLA matched UCB unit with a pre-cryopreserved TNC dose >2.5 x 107 per kilogram recipient weight. HLA matching is initially based on 4 of 6 HLA-A and B (at low or intermediate resolution by molecular typing) and DRB1 ...

    Clinical Trial last updated 06/03/2016 - 2:37pm.

  8. Azacitidine in Haploidentical Donor Hematopoietic Cell Transplantation

    ... (ALL); however, human leukocyte antigen ( HLA )-matched donor availability continues to be a major hurdle. Historically, HLA haploidentical donor hematopoietic cell transplantation (haplo-HCT) was ...

    Clinical Trial last updated 05/03/2016 - 11:15am.

  9. Cord Blood Transplant

    ... peripheral blood from a Human Leukocyte Antigen ( HLA ) matched sibling donor is the most commonly used source of allogeneic stem cells . However, HLA matched siblings are available for less than one third of the patients who ...

    Clinical Trial last updated 04/27/2016 - 9:59am.

  10. Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelopdysplastic Syndrome

    ... Allogeneic bone marrow transplantation from either HLA -matched sibling or matched unrelated donor cures about 70 ... rapidity of availability, requirement of less than perfect HLA match, and lower rates of graft versus host disease compared to mismatched ...

    Clinical Trial last updated 04/25/2016 - 2:18pm.