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  1. Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

    ... and donor have similar human leukocyte antigens ( HLA ). Researchers want to see if the drug palifermin improves the results of allogeneic SCT from HLA-matched unrelated donors. Objective: - To see if high doses of ...

    Clinical Trial last updated 04/29/2016 - 1:00pm.

  2. Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCT (RIC HSCT NMD)

    ... all diagnoses. Patients must have a 4/6, 5/6 or 6/6 HLA matched related or unrelated UCB unit available that will deliver a ... 2x10e7 cells/kg. Patients must have an 8 of 8 or 7 of 8 HLA allele level matched unrelated donor bone marrow or ...

    Clinical Trial last updated 06/13/2016 - 2:18pm.

  3. Safety and Efficacy of Two Doses of ATIR101, a T-lymphocyte Enriched Leukocyte Preparation Depleted of Host Alloreactive T-cells, in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor

    ... family donor with 2 to 3 mismatches at the HLA -A, -B and/or -DR loci of the unshared haplotype Male or female, age ... ATIR101 (e.g., dimethyl sulfoxide) Known presence of HLA antibodies against the non-shared donor haplotype Any other ...

    Clinical Trial last updated 04/29/2016 - 12:25pm.

  4. Resources to Help

    ... Worldwide (BMDW) is the continuing effort to collect the  HLA  phenotypes of volunteer stem cell donors and cord blood units, and is ...

    Topic section last updated 09/28/2017 - 11:58am.

  5. Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

    ... Age, Graft Cell Dose and Graft HLA Criteria Subjects must be <70 years old. Subjects ages ≥ 70 ... (HCT-CI) score ≤ 2. The UCB graft is matched at 4-6 HLA-A, B, DRB1 antigens with the recipient. Patients co-enrolled in ...

    Clinical Trial last updated 05/02/2016 - 2:13pm.

  6. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... undergo allogeneic stem cell transplantation from an HLA identical sibling or match unrelated donor using the identical ... inclusive), and weight > 18kg     Availability of HLA identical or single HLA locus mismatched family donor or 10/10 matched ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.

  7. Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    ... Molecular based human leukocyte antigen ( HLA ) typing will be performed for the HLA-A, -B, -Cw, -DRB1 and -DQB1 loci to the resolution adequate to establish ...

    Clinical Trial last updated 04/29/2016 - 3:26pm.

  8. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... failed HCT An human leukocyte antigen ( HLA )-identical related or an HLA-matched unrelated donor (Fred Hutchinson Cancer Research Center ...

    Clinical Trial last updated 04/28/2016 - 2:45pm.

  9. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... best candidates.   For young patients lacking an HLA -matched sibling donor, immunosuppressive therapy (IST) with ... deciding between IST versus transplant is how quickly an HLA-matched donor can be found and cleared for collection. Donor availability ...

    Interview last updated 11/28/2016 - 2:58pm.

  10. Azacitidine in Haploidentical Donor Hematopoietic Cell Transplantation

    ... (ALL); however, human leukocyte antigen ( HLA )-matched donor availability continues to be a major hurdle. Historically, HLA haploidentical donor hematopoietic cell transplantation (haplo-HCT) was ...

    Clinical Trial last updated 05/03/2016 - 11:15am.