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  1. Bone marrow transplantation versus immunosuppressive therapy in patients with acquired severe aplastic anemia

    ... bone marrow transplantation (BMT), usually from an HLA identical sibling. Whereas long-term survival is comparable with either ... survival (FFS), in patients receiving first-line BMT from an HLA identical sibling, or the first-line IST. Young patients with low ...

    Research Article last updated 07/18/2016 - 10:11am.

  2. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... related (6/6 match for human leukocyte antigen ( HLA )-A and B at intermediate or high resolution and DRB1 at high resolution ... DNA-based typing) or unrelated donor (8/8 match for HLA-A, B, C, and DRB1 at high resolution using DNA-based typing) available. ...

    Clinical Trial last updated 05/22/2017 - 11:00am.

  3. A Comparison of Outcomes for Cord Blood Transplant and Unrelated Bone Marrow Transplant in Adult Aplastic Anemia

    ... To identify differences in outcomes of UCBT and HLA -matched or mismatched unrelated bone marrow transplantation ...

    Research Article last updated 08/15/2016 - 1:06pm.

  4. Resources to Help

    ... Worldwide (BMDW) is the continuing effort to collect the  HLA  phenotypes of volunteer stem cell donors and cord blood units, and is ...

    Topic section last updated 09/28/2017 - 11:58am.

  5. Resources to Help

    ... Worldwide (BMDW) is the continuing effort to collect the  HLA  phenotypes of volunteer stem cell donors and cord blood units, and is ...

    Topic section last updated 09/28/2017 - 11:58am.

  6. Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia

    ... subtype, Karnofsky performance score, graft type, HLA matching, prior aplastic anemia therapy, race/ethnicity, and calendar ... on severe aplastic anemia subtype, recipient age, HLA matching, calendar year of transplant, and conditioning regimen. There was ...

    Research Article last updated 03/03/2015 - 11:48am.

  7. Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC (ExpMACs)

    ... is to expand access for patients who lack a fully HLA ( Human leukocyte antigen ) matched sibling donor and who are ... Patients who lack a fully HLA matched sibling and who are candidates for allogeneic hematopoietic ...

    Clinical Trial last updated 06/13/2016 - 1:47pm.

  8. Alternative donor transplants for severe aplastic anemia: current experience

    ... (SAA), who lack a human leukocyte antigen ( HLA ) identical sibling donor (SIB), have two therapeutic options: ... or a family mismatched member, in most instances genetically HLA haplo-mismatched (HAPLO). In the present review, we will discuss recent ...

    Research Article last updated 06/07/2016 - 10:52am.

  9. Biomarkers for predicting clinical response to immunosuppressive therapy in aplastic anemia

    ... the availability of a human leukocyte antigen ( HLA )-matched donor. Although IST is a promising treatment option, the ... choice for AA patients, including up-front HSCT from HLA-matched unrelated donor . The present review summarizes studies ...

    Research Article last updated 06/22/2016 - 10:19am.

  10. Joseph Oved, MD

    ... that have mutations in certain genes (i.e. PIGA and HLA ) which we believe are necessary for the immune system to recognize and ...

    Grant Recipient last updated 06/08/2017 - 10:40am.