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  1. Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor

    ... for bone marrow transplants do not have an HLA -matched, or close to matched, donor available. For this reason, doctors have been testing ways to make transplants from HLA-partially matched donors as safe and effective as transplants from ...

    Clinical Trial last updated 04/29/2016 - 1:59pm.

  2. Alternative donor transplants for severe aplastic anemia: current experience

    ... (SAA), who lack a human leukocyte antigen ( HLA ) identical sibling donor (SIB), have two therapeutic options: ... or a family mismatched member, in most instances genetically HLA haplo-mismatched (HAPLO). In the present review, we will discuss recent ...

    Research Article last updated 06/07/2016 - 10:52am.

  3. Current Outcome of HLA Identical Sibling vs Unrelated Donor Transplants in Severe Aplastic Anemia: An EBMT Analysis

    ... healthy stem cells come from a sibling who has the same HLA (immune system) markers as the patient. HSCT from an HLA-matched, unrelated donor appears to have poorer outcomes than from ...

    Research Review last updated 05/02/2016 - 9:20am.

  4. Reduced Intensity Conditioning and Haploidentical Related Bone Marrow for Patients With Hematologic Diseases

    ... This is a treatment guideline for HLA -Haploidentical hematopoietic stem cell transplant (HSCT) using ... Must be <75 years old with no 7/8 or 8/8 HLA -matched sibling donor One or more potential related mismatched ...

    Clinical Trial last updated 06/06/2016 - 10:54am.

  5. HLA-Matched Sibling Transplantation for Severe Aplastic Anemia: Impact of HLA DR15 Antigen Status on Engraftment, Graft-versus-Host Disease, and Overall Survival.

    ... The HLA class II DRB1 antigen DR15 (common alleles *1501, *1502) is an ... aplastic anemia (SAA). We studied 1204 recipients of HLA-matched sibling bone marrow transplantation for SAA to determine ...

    Research Article last updated 06/15/2012 - 2:55pm.

  6. Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

    ... commonly involved the human leukocyte antigen ( HLA ) locus, leading to loss of one HLA haplotype. Loss of HLA-A expression from multiple lineages of leukocytes ...

    Research Article last updated 10/12/2011 - 3:13pm.

  7. Clinical Trials Report for April 2016

    ... for patients with human leukocyte antigen ( HLA ) matched unrelated (MUD) and mismatched unrelated (MMUD) donors. ...

    Page last updated 08/10/2016 - 11:00am.

  8. Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease

    ... and assess complication rates for genetically ( HLA ) matched related donor combined ... 18 - 65 years of age. Participants must have an HLA -matched or one of six HLA A, B, or DR antigen-mismatched related donor, ...

    Clinical Trial last updated 06/06/2016 - 3:04pm.

  9. T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts (MOHEL)

    For more details on this clinical trial, including contact information, please see this trial’s listing on clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/NCT00368355 ...

    Clinical Trial last updated 04/28/2016 - 12:15pm.

  10. Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCT (RIC HSCT NMD)

    ... all diagnoses. Patients must have a 4/6, 5/6 or 6/6 HLA matched related or unrelated UCB unit available that will deliver a ... 2x10e7 cells/kg. Patients must have an 8 of 8 or 7 of 8 HLA allele level matched unrelated donor bone marrow or ...

    Clinical Trial last updated 06/13/2016 - 2:18pm.