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  1. Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC (ExpMACs)

    ... is to expand access for patients who lack a fully HLA ( Human leukocyte antigen ) matched sibling donor and who are ... Patients who lack a fully HLA matched sibling and who are candidates for allogeneic hematopoietic ...

    Clinical Trial last updated 06/13/2016 - 1:47pm.

  2. Natural Killer (NK) Cells With HLA Compatible Hematopoietic Transplantation for High Risk Myeloid Malignancies

    ... or blast crisis. Patient must have an identified a HLA (A,B,C,DR) compatible related or unrelated donor who is age 16 ...

    Clinical Trial last updated 06/06/2016 - 1:18pm.

  3. Alternative donor transplants for severe aplastic anemia: current experience

    ... (SAA), who lack a human leukocyte antigen ( HLA ) identical sibling donor (SIB), have two therapeutic options: ... or a family mismatched member, in most instances genetically HLA haplo-mismatched (HAPLO). In the present review, we will discuss recent ...

    Research Article last updated 06/07/2016 - 10:52am.

  4. Reduced Intensity Conditioning and Haploidentical Related Bone Marrow for Patients With Hematologic Diseases

    ... This is a treatment guideline for HLA -Haploidentical hematopoietic stem cell transplant (HSCT) using ... Must be <75 years old with no 7/8 or 8/8 HLA -matched sibling donor One or more potential related mismatched ...

    Clinical Trial last updated 06/06/2016 - 10:54am.

  5. Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCT (RIC HSCT NMD)

    ... all diagnoses. Patients must have a 4/6, 5/6 or 6/6 HLA matched related or unrelated UCB unit available that will deliver a ... 2x10e7 cells/kg. Patients must have an 8 of 8 or 7 of 8 HLA allele level matched unrelated donor bone marrow or ...

    Clinical Trial last updated 06/13/2016 - 2:18pm.

  6. Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies

    ... (HSCT) from Human Leukocyte Antigen ( HLA )-mismatched related donors for children and young adults with ... Available related donor who is mismatched at ≥ 2 HLA alleles Exclusion Criteria:  Available HLA -identical related donor HIV positive Active uncontrolled ...

    Clinical Trial last updated 04/29/2016 - 10:59am.

  7. Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease

    ... and assess complication rates for genetically ( HLA ) matched related donor combined ... 18 - 65 years of age. Participants must have an HLA -matched or one of six HLA A, B, or DR antigen-mismatched related donor, ...

    Clinical Trial last updated 06/06/2016 - 3:04pm.

  8. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... cell transplant (alloSCTx) or not have a known fully HLA matched sibling for planned sibling transplant. Patients must have ... has at least one medically fit family member expected to be HLA mismatched at 1-9/10; more commonly and preferred: 4-6/10 loci (parent, ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.

  9. CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease

    ... U. S. Department of Health and Human Services. HLA typing will be performed by high resolution molecular DNA typing for HLA Class I A, B, and C and HLA Class II DRB1 and DQB1 alleles. ...

    Clinical Trial last updated 06/13/2016 - 2:06pm.

  10. Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children

    ... Patient with a human leukocyte antigen ( HLA )-identical (HLA-A, B, C, and ribonucleic acid [RNA] binding motif protein 45 [DRB1] ...

    Clinical Trial last updated 06/13/2016 - 2:29pm.