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  1. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... bone marrow and peripheral blood from HLA antigen-haploidentical donors (3 cases) or peripheral blood only from unrelated HLA antigen-identical donors (3 cases). MSCs were intravenously injected at a ...

    Research Article last updated 07/30/2012 - 1:18pm.

  2. Successful bone marrow transplantation for children with aplastic anemia based on a best-available evidence strategy.

    ... had ATG + CY + Flu, and five had ATG + CY. Donors were HLA -matched siblings in 10, HLA-mismatched family in one, HLA-matched unrelated in three, and ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Impact of age on outcomes after bone marrow transplantation for acquired aplastic anemia using HLA-matched sibling donors.

    ... BACKGROUND: Transplantation from an HLA -matched sibling is the treatment of choice for young patients with ... in 1307 patients with severe aplastic anemia after HLA-matched sibling transplantation using logistic and Cox regression ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... to 60 years (median 32 years). Twenty-three donors were HLA -identical (22 siblings and one unrelated) and 3 were HLA-mismatched (2 related and one unrelated). RESULTS: Fifteen ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Reduced-intensity hematopoietic cell transplantation in older patients with AML/MDS: umbilical cord blood is a feasible option for patients without HLA-matched sibling donors

    ... cell transplantation (HCT) for patients without HLA -matched sibling donors (MSD). We compared outcomes of HCT using MSD ... 95% received two UCB units and 88% received 1-2 locus HLA-mismatched units to optimize cell dose. OS at 3-years was 37% for MSD and ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Improved outcome of patients older than 30 years receiving HLA-identical sibling hematopoietic stem cell transplantation for severe acquired aplastic anemia using fludarabine-based conditioning: a comparison with conventional conditioning regimen.

    ... Older age is a limitation for HLA -identical sibling hematopoietic stem cell transplantation (HSCT) as ... impact of age in older patients with SAA receiving an HLA-identical sibling HSCT. ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor

    ... for bone marrow transplants do not have an HLA -matched, or close to matched, donor available. For this reason, doctors have been testing ways to make transplants from HLA-partially matched donors as safe and effective as transplants from ...

    Clinical Trial last updated 04/29/2016 - 1:59pm.

  8. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    ... stem cell transplantation as first line therapy if an HLA -identical sibling is identified; the use of first-line IST containing ... globulin and cyclosporine A (CSA) if an HLA-identical sibling donor is not identified; supportive care ...

    Research Article last updated 12/17/2013 - 8:30am.

  9. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... related (6/6 match for human leukocyte antigen ( HLA )-A and B at intermediate or high resolution and DRB1 at high resolution ... DNA-based typing) or unrelated donor (8/8 match for HLA-A, B, C, and DRB1 at high resolution using DNA-based typing) available. ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  10. Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes

    ... MAC (n = 135) or RIC (n = 137) followed by HCT from HLA -matched related or unrelated donors. The primary end point was OS 18 ...

    Research Article last updated 05/02/2017 - 10:29am.