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  1. First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor vs. immunosuppressive therapy

    ... underwent bone marrow transplantation from an HLA -matched family donor registered in the Japan Society for Hematopoietic ... anemia received bone marrow transplantation from an HLA-matched family donor (n=213) or immunosuppressive therapy (n=386) as ...

    Research Article last updated 09/24/2014 - 10:16am.

  2. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... patients with debilitating PNH, including 8 who were HLA -alloimmunized, underwent a reduced intensity allogeneic hematopoietic ... +/- ATG followed by a G-CSF mobilized HCT from an HLA-matched relative. GPI-negative neutrophils were detectable following ...

    Research Article last updated 06/02/2014 - 11:39am.

  3. Allogeneic BM transplantation for the treatment of aplastic anemia: current results and expanding donor possibilities

    ... Allogeneic BM transplantation from an HLA -identical sibling donor leads to long-term survival in the majority of ... of immunosuppressive therapy. After transplantation from an HLA-identical sibling donor or from an unrelated one, the use of peripheral ...

    Research Article last updated 01/07/2014 - 12:31pm.

  4. Impact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS)

    ... (HCT) from human leukocyte antigen ( HLA ) matched related donor (MRD) and matched unrelated donors (MUD) ... HCT between 2002 and 2006 were analyzed (MRD, n=176; 8/8 HLA-A, B, C, DRB1 allele matched MUD, n=413; 7/8 MUD, n=112). Median age was 53 ...

    Research Article last updated 08/06/2013 - 2:12pm.

  5. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... bone marrow and peripheral blood from HLA antigen-haploidentical donors (3 cases) or peripheral blood only from unrelated HLA antigen-identical donors (3 cases). MSCs were intravenously injected at a ...

    Research Article last updated 07/30/2012 - 1:18pm.

  6. Impact of age on outcomes after bone marrow transplantation for acquired aplastic anemia using HLA-matched sibling donors.

    ... BACKGROUND: Transplantation from an HLA -matched sibling is the treatment of choice for young patients with ... in 1307 patients with severe aplastic anemia after HLA-matched sibling transplantation using logistic and Cox regression ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Successful bone marrow transplantation for children with aplastic anemia based on a best-available evidence strategy.

    ... had ATG + CY + Flu, and five had ATG + CY. Donors were HLA -matched siblings in 10, HLA-mismatched family in one, HLA-matched unrelated in three, and ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... to 60 years (median 32 years). Twenty-three donors were HLA -identical (22 siblings and one unrelated) and 3 were HLA-mismatched (2 related and one unrelated). RESULTS: Fifteen ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Reduced-intensity hematopoietic cell transplantation in older patients with AML/MDS: umbilical cord blood is a feasible option for patients without HLA-matched sibling donors

    ... cell transplantation (HCT) for patients without HLA -matched sibling donors (MSD). We compared outcomes of HCT using MSD ... 95% received two UCB units and 88% received 1-2 locus HLA-mismatched units to optimize cell dose. OS at 3-years was 37% for MSD and ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor

    ... for bone marrow transplants do not have an HLA -matched, or close to matched, donor available. For this reason, doctors have been testing ways to make transplants from HLA-partially matched donors as safe and effective as transplants from ...

    Clinical Trial last updated 04/29/2016 - 1:59pm.