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  1. Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

    ... be an 8/8 match for human leukocyte antigen ( HLA )-A, -B, and -C at intermediate (or higher) resolution, and -DRB1 at ... for donation1. Unrelated donor must be an 8/8 match at HLA-A, -B, -C and -DRB1 at high resolution using DNA-based typing. Unrelated ...

    Clinical Trial last updated 06/06/2016 - 1:36pm.

  2. TCRαβ+/CD19+ Depleted Haploidentical HSCT + Zoledronate

    ... Patients with hematologic malignancy must have no HLA identical sibling or suitable unrelated donor OR time needed to ...

    Clinical Trial last updated 04/29/2016 - 4:35pm.

  3. Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

    ... severe sickle cell disease (SCD) and B-thalassemia from HLA -matched family donors has excellent results thus far. Our long term ... approach in the patients with SCD and B-thalassemia with HLA-matched family donors, but using an increased intensity regimen in a subset ...

    Clinical Trial last updated 04/28/2016 - 9:09am.

  4. Cytoxan, Fludara, and Antithymocyte Globulin Conditioning Followed By Stem Cell Transplant in Treating Fanconi Anemia

    ... and antithymocyte globulin followed by HLA -genotypically identical sibling donor hematopoietic stem cell ...

    Clinical Trial last updated 04/28/2016 - 8:53am.

  5. Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia

    ... Patients are stratified according to donor/recipient HLA type (identical vs other). Cytoreductive combination ...

    Clinical Trial last updated 04/28/2016 - 8:49am.

  6. Post Transplant Cyclophosphamide (Cytoxan) for GvHD Prophylaxis

    ... for patients with human leukocyte antigen ( HLA ) matched unrelated (MUD) and mismatched unrelated (MMUD) donors. Other ...

    Clinical Trial last updated 04/27/2016 - 9:38am.

  7. Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant and Cyclophosphamide, Mycophenolate Mofetil, Tacrolimus, and Sirolimus in Treating Patients With Primary Immunodeficiency Disorders or Noncancerou

    ... (HCT) from human leukocyte antigen ( HLA )-haploidentical related donors for patients with nonmalignant inherited disorders who do not have an HLA-matched related or unrelated donor . SECONDARY OBJECTIVES: ...

    Clinical Trial last updated 04/26/2016 - 2:09pm.

  8. Transplantation Update

    ... complications. Outcome tends to be better with HLA -matched related donors than with unrelated donors. Sources of Stem ... At Hutchinson, we’re looking at cord blood cells from HLA haploidentical donors only if we can’t find an HLA matched related or ...

    Interview last updated 05/14/2015 - 2:42pm.

  9. Safety and Efficacy of Patient's Own AD-MSC and AD-HSC Transplantation in Patients With Severe Aplastic Anemia

    ... using an human leukocyte antigen ( HLA ) matched sibling donor, only about 25% of patients have such a donor. ...

    Clinical Trial last updated 04/08/2016 - 11:25pm.

  10. Bone Marrow Transplant

    ... a suitable match with the patient's type. This is called HLA matching. A well-matched donor is important to the success of the ...

    Topic section last updated 03/29/2016 - 7:27pm.