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  1. Alternative donor transplantation for aplastic anemia.

    ... who do not have a human leukocyte antigen ( HLA )-identical sibling generally receive immunosuppressive therapy as a ... of Caucasian descent will have an available and fully HLA-matched unrelated adult donor; the rate is substantially lower for ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Granulocyte transfusions in severe aplastic anemia: an eleven-year experience.

    ... absolute neutrophil count, stratified by HLA alloimmunization status. RESULTS: Thirty-two patients with ... A. One quarter of patients had demonstrable HLA alloimmunization prior to the initiation of granulocyte therapy. ... neutrophil count between the patients divided according to HLA alloimmunization status. CONCLUSIONS: Granulocyte transfusions ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Non-myeloablative peripheral blood haploidentical stem cell transplantation for refractory severe aplastic anemia

    ... Graft failure was associated with donor-directed HLA antibodies, despite intensive pre-HSCT desensitization with plasma ... rescue refractory SAA patients who lack donor-directed HLA antibodies but not in the presence of donor-directed HLA antibodies. This ...

    Research Article last updated 08/04/2014 - 8:20am.

  4. Contribution of Revised International Prognostic Scoring System Cytogenetics to Predict Outcome After Allogeneic Stem Cell Transplantation for Myelodysplastic Syndromes: A Study From the French Society of Bone Marrow Transplantation and Cellular Therapy

    ... on the outcome of 367 MDS patients transplanted from HLA -identical siblings or HLA allele-matched unrelated donors. RESULTS: According to the ...

    Research Article last updated 04/08/2015 - 9:59am.

  5. First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor vs. immunosuppressive therapy

    ... underwent bone marrow transplantation from an HLA -matched family donor registered in the Japan Society for Hematopoietic ... anemia received bone marrow transplantation from an HLA-matched family donor (n=213) or immunosuppressive therapy (n=386) as ...

    Research Article last updated 09/24/2014 - 10:16am.

  6. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... patients with debilitating PNH, including 8 who were HLA -alloimmunized, underwent a reduced intensity allogeneic hematopoietic ... +/- ATG followed by a G-CSF mobilized HCT from an HLA-matched relative. GPI-negative neutrophils were detectable following ...

    Research Article last updated 06/02/2014 - 11:39am.

  7. Allogeneic BM transplantation for the treatment of aplastic anemia: current results and expanding donor possibilities

    ... Allogeneic BM transplantation from an HLA -identical sibling donor leads to long-term survival in the majority of ... of immunosuppressive therapy. After transplantation from an HLA-identical sibling donor or from an unrelated one, the use of peripheral ...

    Research Article last updated 01/07/2014 - 12:31pm.

  8. Impact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS)

    ... (HCT) from human leukocyte antigen ( HLA ) matched related donor (MRD) and matched unrelated donors (MUD) ... HCT between 2002 and 2006 were analyzed (MRD, n=176; 8/8 HLA-A, B, C, DRB1 allele matched MUD, n=413; 7/8 MUD, n=112). Median age was 53 ...

    Research Article last updated 08/06/2013 - 2:12pm.

  9. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... bone marrow and peripheral blood from HLA antigen-haploidentical donors (3 cases) or peripheral blood only from unrelated HLA antigen-identical donors (3 cases). MSCs were intravenously injected at a ...

    Research Article last updated 07/30/2012 - 1:18pm.

  10. Successful bone marrow transplantation for children with aplastic anemia based on a best-available evidence strategy.

    ... had ATG + CY + Flu, and five had ATG + CY. Donors were HLA -matched siblings in 10, HLA-mismatched family in one, HLA-matched unrelated in three, and ...

    Research Article last updated 10/11/2011 - 5:58pm.