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  1. Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

    ... thought to be driven by human leukocyte antigen ( HLA )–restricted T cell immunity, with earlier studies favoring HLA class II-mediated pathways. Using whole-exome sequencing (WES), we recently ...

    Research Article last updated 10/23/2017 - 10:56am.

  2. HLA-Matched Sibling Transplantation for Severe Aplastic Anemia: Impact of HLA DR15 Antigen Status on Engraftment, Graft-versus-Host Disease, and Overall Survival.

    ... 28, 2012 The HLA class II DRB1 antigen DR15 (common alleles *1501, *1502) is an ... aplastic anemia (SAA). We studied 1204 recipients of HLA-matched sibling bone marrow transplantation for SAA to determine ...

    Research Article last updated 06/15/2012 - 2:55pm.

  3. Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

    ... commonly involved the human leukocyte antigen ( HLA ) locus, leading to loss of one HLA haplotype. Loss of HLA-A expression from multiple lineages of leukocytes ...

    Research Article last updated 10/12/2011 - 3:13pm.

  4. Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... risk index (DRI)-matched patient age ≥ 65 undergoing HLA -matched unrelated donor (MUD) HCT for AML or MDS during the ...

    Research Article last updated 11/14/2017 - 10:09am.

  5. Repurposing older drugs to help prevent GVHD

    ... to receive myeloablative HCT from an available 8/8- HLA matched URD. Patients received GVHD prophylaxis with tacrolimus and ...

    Article last updated 10/18/2017 - 8:48am.

  6. Haploidentical transplant in patients with myelodysplastic syndrome

    ... risk and the type of donor. In patients without an HLA -matched sibling donor, a family haploidentical donor is an alternative ... A total of 228 patients transplanted from a mismatched HLA-related donor between 2007 and 2014 were studied. The median age at ...

    Research Article last updated 10/04/2017 - 9:19am.

  7. Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies

    ... (HSCT) from Human Leukocyte Antigen ( HLA )-mismatched related donors for children and young adults with ... Available related donor who is mismatched at ≥ 2 HLA alleles Exclusion Criteria:  ...

    Clinical Trial last updated 04/29/2016 - 10:59am.

  8. Allogeneic transplant: does age still matter?

    ... of reduced or nonmyeloablative regimens, and improved HLA matching. Despite an increase in unrelated donor availability, ...

    Article last updated 08/31/2017 - 2:17pm.

  9. Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes

    ... MAC (n = 135) or RIC (n = 137) followed by HCT from HLA -matched related or unrelated donors. The primary end point was OS 18 ...

    Research Article last updated 05/02/2017 - 10:29am.

  10. Effect of antithymocyte globulin source on outcomes of bone marrow transplantation for severe aplastic anemia

    ... aplastic anemia transplants between 2008 and 2013 using HLA -matched siblings (n=546) or unrelated donors (n=287) who received ... by type of antithymocyte globulin. Among recipients of HLA-matched sibling transplants, day 100 incidence of acute (17% versus 6%, ...

    Research Article last updated 04/14/2017 - 1:06pm.