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  1. Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

    ... thought to be driven by human leukocyte antigen ( HLA )–restricted T cell immunity, with earlier studies favoring HLA class II-mediated pathways. Using whole-exome sequencing (WES), we recently ...

    Research Article last updated 10/23/2017 - 10:56am.

  2. HLA-Matched Sibling Transplantation for Severe Aplastic Anemia: Impact of HLA DR15 Antigen Status on Engraftment, Graft-versus-Host Disease, and Overall Survival.

    ... The HLA class II DRB1 antigen DR15 (common alleles *1501, *1502) is an ... aplastic anemia (SAA). We studied 1204 recipients of HLA-matched sibling bone marrow transplantation for SAA to determine ...

    Research Article last updated 06/15/2012 - 2:55pm.

  3. Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

    ... commonly involved the human leukocyte antigen ( HLA ) locus, leading to loss of one HLA haplotype. Loss of HLA-A expression from multiple lineages of leukocytes ...

    Research Article last updated 10/12/2011 - 3:13pm.

  4. Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies

    ... (HSCT) from Human Leukocyte Antigen ( HLA )-mismatched related donors for children and young adults with ... Available related donor who is mismatched at ≥ 2 HLA alleles Exclusion Criteria:  Available HLA -identical related donor HIV positive Active uncontrolled ...

    Clinical Trial last updated 04/29/2016 - 10:59am.

  5. Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... risk index (DRI)-matched patient age ≥ 65 undergoing HLA -matched unrelated donor (MUD) HCT for AML or MDS during the ...

    Research Article last updated 11/14/2017 - 10:09am.

  6. Repurposing older drugs to help prevent GVHD

    ... to receive myeloablative HCT from an available 8/8- HLA matched URD. Patients received GVHD prophylaxis with tacrolimus and ...

    Article last updated 10/18/2017 - 8:48am.

  7. Haploidentical transplant in patients with myelodysplastic syndrome

    ... risk and the type of donor. In patients without an HLA -matched sibling donor, a family haploidentical donor is an alternative ... A total of 228 patients transplanted from a mismatched HLA-related donor between 2007 and 2014 were studied. The median age at ...

    Research Article last updated 10/04/2017 - 9:19am.

  8. Stem Cell Transplantation: What Happens Behind the Scenes?

    ... family members are not a match. I review the patient’s HLA typing, enter that data into the National Marrow Donor Program (Be the ... referred. Stem cell transplant coordinators get the HLA typing completed, send testing kits out to family members, and run searches ...

    Interview last updated 01/18/2018 - 1:28pm.

  9. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... related (6/6 match for human leukocyte antigen ( HLA )-A and B at intermediate or high resolution and DRB1 at high resolution ... DNA-based typing) or unrelated donor (8/8 match for HLA-A, B, C, and DRB1 at high resolution using DNA-based typing) available. ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  10. Allogeneic transplant: does age still matter?

    ... of reduced or nonmyeloablative regimens, and improved HLA matching. Despite an increase in unrelated donor availability, ...

    Article last updated 08/31/2017 - 2:17pm.