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  1. Stem Cell Transplantation: What Happens Behind the Scenes?

    ... family members are not a match. I review the patient’s HLA typing, enter that data into the National Marrow Donor Program (Be the ... referred. Stem cell transplant coordinators get the HLA typing completed, send testing kits out to family members, and run searches ...

    Interview last updated 01/18/2018 - 1:28pm.

  2. Daria Babushok, MD, PhD

    ... through loss of Human Leukocyte Antigen ( HLA ) genes. The mutations were present in a significant portion of early ...

    Grant Recipient last updated 01/12/2018 - 9:44am.

  3. Resources to Help

    ... Worldwide (BMDW) is the continuing effort to collect the  HLA  phenotypes of volunteer stem cell donors and cord blood units, and is ...

    Topic section last updated 01/04/2018 - 2:11pm.

  4. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... related (6/6 match for human leukocyte antigen ( HLA )-A and B at intermediate or high resolution and DRB1 at high resolution ... DNA-based typing) or unrelated donor (8/8 match for HLA-A, B, C, and DRB1 at high resolution using DNA-based typing) available. ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  5. Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

    ... thought to be driven by human leukocyte antigen ( HLA )–restricted T cell immunity, with earlier studies favoring HLA class II-mediated pathways. Using whole-exome sequencing (WES), we recently ...

    Research Article last updated 10/23/2017 - 10:56am.

  6. Haploidentical Hematopoietic Cell Transplant with Post-Transplant Cyclophosphamide and Peripheral Blood Stem Cell Grafts in Older Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... risk index (DRI)-matched patient age ≥ 65 undergoing HLA -matched unrelated donor (MUD) HCT for AML or MDS during the ...

    Research Article last updated 11/14/2017 - 10:09am.

  7. Repurposing older drugs to help prevent GVHD

    ... to receive myeloablative HCT from an available 8/8- HLA matched URD. Patients received GVHD prophylaxis with tacrolimus and ...

    Article last updated 10/18/2017 - 8:48am.

  8. Haploidentical transplant in patients with myelodysplastic syndrome

    ... risk and the type of donor. In patients without an HLA -matched sibling donor, a family haploidentical donor is an alternative ... A total of 228 patients transplanted from a mismatched HLA-related donor between 2007 and 2014 were studied. The median age at ...

    Research Article last updated 10/04/2017 - 9:19am.

  9. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... using alternative donors for patients who lack an HLA identical sibling or unrelated donors. This work that we began aimed at helping patients that did not have an HLA matched donor started about 12 years ago. This is when we tried to come up ...

    Interview last updated 10/04/2017 - 1:36pm.

  10. Resources to Help

    ... Worldwide (BMDW) is the continuing effort to collect the  HLA  phenotypes of volunteer stem cell donors and cord blood units, and is ...

    Topic section last updated 09/28/2017 - 11:58am.