Self-reported sleep disturbance and survival in myelodysplastic syndromes | Aplastic Anemia and MDS International Foundation

Self-reported sleep disturbance and survival in myelodysplastic syndromes

Journal Title: 
Br J Haematol
Primary Author: 
Luskin MR
Author(s): 
Luskin MR, Cronin AM, Owens RL, DeAngelo DJ, Stone RM, Wadleigh M, Steensma DP, Abel GA
Original Publication Date: 
Wednesday, March 8, 2017

Neither the prevalence of sleep disturbance nor its association with fatigue and overall survival (OS) are well understood for patients with myelodysplastic syndromes (MDS). New patients at our institution (n = 251; 2006-2014) completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, which includes questions about sleep and fatigue. Fifty-three per cent reported at least 'a little' trouble sleeping. In multivariable models, anaemia and sleep disturbance were associated with fatigue (both P < 0·001). Additionally, in separate models, sleep disturbance (P = 0·002) and fatigue (P = 0·04) both predicted OS. Our data suggest that improving sleep quality may impact MDS-related fatigue and OS.

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