Patients & Caregivers

Research Review for Patients

Reviews listed here focus on important medical journal articles on bone marrow failure disease. These reviews are written by hematology/oncology professionals who interpret the most relevant information for patients from the latest published research.

A listing of recent articles from major hematology/oncology journals, retrieved from the National Library of Medicine MEDLINE database is available in the Latest Research section of the Web site.

You can also read Research Summaries for Patients that are lay language explanations of scientific meetings and symposia.

Originally published on 05/30/2012 - 8:07pm. Last updated on Wed, 07/11/2012 - 2:09pm.
Myelodysplastic Syndromes are a collection of diseases with common, but also different characteristics
Friday, March 29, 2013 by Vivienne Rebel, M.D., Ph.D.
Myelodysplastic syndrome (MDS) is not a disease that follows a standard path; especially time of survival after diagnosis and the risk to develop leukemia is highly variable among patients. It is therefore believed that MDS represents not one but a group of diseases.  Indeed, there are several systems in place...
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Identification of genetic abnormalities in MDS patients that may lead to a better diagnosis and treatment strategy of MDS patients
Friday, March 29, 2013 by Vivienne Rebel, M.D., Ph.D.
Myelodysplastic syndrome (MDS) represents a group of diseases that can be subdivided into various categories based on clinical, pathological and certain genetic abnormalities.  Subclassification of MDS, especially in terms of predicted risk for a good or bad outcome, is important because it helps doctors to...
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Even "Moderate" Dose Cyclophosphamide for Severe Aplastic Anemia Is Associated with Significant Toxicities and Does Not Prevent Relapse and Clonal Evolution
Monday, February 25, 2013 by Katherine Walsh, MD
Note: This review is based upon two presentations at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the...
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Improved Outcome of Reduced Toxicity Fludarabine, Cyclophosphamide Plus Thymoglobulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of Two Multicenter Prospective Studies
Monday, February 25, 2013 by Katherine Walsh, MD
Note: This review is based upon two presentations at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the...
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Very Short Telomeres of Peripheral Blood Leukocytes Precede Clinical Progression to Myelodysplasia with Monosomy 7 in Aplastic Anemia Patients
Monday, January 28, 2013 by Stephanie Halene, MD
Note: This review is based upon two presentations at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the...
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Clinical and Genetic Heterogeneity of Telomere Diseases
Monday, January 28, 2013 by Stephanie Halene, MD
Note: This review is based upon two presentations at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full...
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Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)
Tuesday, January 1, 2013 by David J. Araten, MD
Note: This review is based upon a presentation at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia.The full abstract may be reviewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full...
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A Rare Genetic Polymorphism in C5 Confers Poor Response to the Anti-C5 Monoclonal Antibody Eculizumab by Nine Japanese Patients with PNH
Tuesday, January 1, 2013 by David J. Araten, MD
Note: This review is based upon a presentation at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia.The full abstract may be reviewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full...
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Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro
Tuesday, January 1, 2013 by David J. Araten, MD
Note: This review is based upon a presentation at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia.The full abstract may be reviewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full...
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Genetic Polymorphism of the Complement Receptor-1 (CR1) Gene Correlates with the Clinical Response to Eculizumab of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)
Tuesday, January 1, 2013 by David J. Araten, MD
Note: This review is based upon a presentation at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia.The full abstract may be reviewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full...
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