What causes aplastic anaemia?
Aplastic anaemia has diverse aetiologies including: (1) direct damage to haematopoietic stem or progenitor cells such as from chemicals, drugs and ionising radiations; (2) an abnormal bone marrow micro-environment, (3) immune-mediated mechanism(s); or (4) combination of these. Aetiologies may differ between persons with similar phenotypes and even genotypes [1] (References in the Supplementary).