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What causes aplastic anaemia?

Author(s): 
Gale RP, Hinterberger W, Young NS, Gennery AR, Dvorak CC, Hebert KM, Heim M, Broglie L, Eapen M
Primary Author: 
Gale RP
Journal Title: 
Leukemia
Original Publication Date: 
Apr 2023

Aplastic anaemia has diverse aetiologies including: (1) direct damage to haematopoietic stem or progenitor cells such as from chemicals, drugs and ionising radiations; (2) an abnormal bone marrow micro-environment, (3) immune-mediated mechanism(s); or (4) combination of these. Aetiologies may differ between persons with similar phenotypes and even genotypes [1] (References in the Supplementary).

Bone Marrow Disease(s):