Can G-CSF Cause Leukemia in Hematopoietic Stem Cell Donors? | Aplastic Anemia and MDS International Foundation

Can G-CSF Cause Leukemia in Hematopoietic Stem Cell Donors?

Journal Title: 
Biol Blood Marrow Transplant.
Author(s): 
Avalos BR, Lazaryan A, Copelan EA.
Primary Author: 
Avalos BR
Original Publication Date: 
Wednesday, July 13, 2011

A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances. Although clinical data to date have failed to identify any increased incidence of MDS/AML in G-CSF mobilized donors, the quality of these data are insufficient to exclude a long-term risk. Physicians should explain the potential risk to donors, and where appropriate, offer donors the option of marrow donation.

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