Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant | Aplastic Anemia and MDS International Foundation

Clinical Trial: NCT02333162

Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant
For more details on this clinical trial, including contact information, please see this trial’s listing on clinicaltrials.gov:
Purpose: 

This phase I trial studies the side effects and the best dose of intensity modulated total marrow irradiation (IMTMI) when given together with fludarabine phosphate and melphalan in treating patients with cancers of the blood (hematologic) that have returned after a period of improvement (relapsed) undergoing a second donor stem cell transplant. IMTMI is a type of radiation therapy to the bone marrow that may be less toxic and may also reduce the chances of cancer to return. Giving fludarabine phosphate, melphalan, and IMTMI before a donor stem cell transplant may help stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.

Status: 
Recruiting
Study Date: 
Mon, 12/01/2014 to Wed, 11/01/2017
Bone Marrow Disease(s): 
myelodysplastic syndromes (MDS)
Associated Drug(s): 
Intervention: 
Drug: Fludarabine Phosphate Given IV Other Names: 2-F-ara-AMP Beneflur SH T 586 Drug: Melphalan Given IV Other Name: Alkeran Radiation: Intensity-Modulated Radiation Therapy Undergo IMTMI Other Names: IMRT Intensity Modulated RT Intensity-Modulated Radiotherapy Radiation: Total Marrow Irradiation Undergo IMTMI Procedure: Allogeneic Hematopoietic Stem Cell Transplantation Undergo allogeneic PBSCT Other Names: HSC HSCT Procedure: Peripheral Blood Stem Cell Transplantation Undergo allogeneic PBSCT Other Names: PBPC transplantation Peripheral Blood Progenitor Cell Transplantation Peripheral Stem Cell Support Peripheral Stem Cell Transplantation Procedure: Allogeneic Bone Marrow Transplantation Undergo allogeneic BMT Other Names: Allo BMT Allogeneic BMT Drug: Tacrolimus Given IV or PO Other Names: Advagraf FK 506 Drug: Mycophenolate Mofetil Given IV or PO Other Names: Cellcept MMF Other: Laboratory Biomarker Analysis Correlative studies