Reduced Intensity Double Umbilical Cord Blood Transplantation | Aplastic Anemia and MDS International Foundation

Clinical Trial: NCT01408563

Reduced Intensity Double Umbilical Cord Blood Transplantation
For more details on this clinical trial, including contact information, please see this trial’s listing on clinicaltrials.gov:
Purpose: 

Subjects will receive their transplants as in-patients.

  • IV-Catheter

    • one or two IV catheters will be placed on the day of hospital admission
  • Conditioning

    • Fludarabine IV six days before transplant (days -7, -6, -5. -4, -3, -2)
    • Melphalan IV (day -1)
    • Total body radiation on day 0 (same day as transplant)
  • Immunosuppressive Therapy

    • Tacrolimus and sirolimus beginning day -3, daily for 6-9 months post-transplant. Given IV as in-patient, orally as out-patient
  • Infusion of Cord Blood units

    • 2 cord blood units IV on Day 0 Routine post-transplant supportive care will be provided
Status: 
Recruiting
Study Date: 
Tue, 08/02/2011 to Mon, 08/01/2016
Bone Marrow Disease(s): 
aplastic anemia
Associated Drug(s): 
Intervention: 
Drug: Fludarabine 30 mg/m2/day IV x 6 days Other Name: Fludara Drug: Melphalan 100 mg/m2/day IV x 1 day Radiation: Total Body Radiation 200 cGy on Day 0 Biological: Cord Blood 2 cord blood units IV