Aplastic anemia: first-line treatment by immunosuppression and sibling marrow transplantation. | Aplastic Anemia and MDS International Foundation

Aplastic anemia: first-line treatment by immunosuppression and sibling marrow transplantation.

Journal Title: 
Hematology Am Soc Hematol Educ Program
Author(s): 
Passweg JR, Marsh JC.
Primary Author: 
Passweg JR
Original Publication Date: 
Friday, January 1, 2010

Newly diagnosed aplastic anemia is a serious condition, with more than 75% (higher in young patients) becoming long-term survivors if diagnosed and treated appropriately. First-line treatment approaches include immunosuppressive treatment using the combination of antithymocyte globulin and cyclosporine A for patients without a sibling donor and HLA identical sibling transplant for patients younger than age 40 with a donor. Best transplant strategies have been defined and include conditioning with cyclophosphamide and antithymocyte globulin, marrow as a stem cell source, and graft-versus-host diease prophylaxis using cyclosporine A and methotrexate. It is against these standard treatment approaches that any therapeutic progress has to be measured.

Bone Marrow Diseases: