Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia | Aplastic Anemia and MDS International Foundation

Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia

Journal Title: 
Leuk Res Rep
Author(s): 
Purev E, Dumitriu B, Hourigan CS, Young NS, Townsley DM
Primary Author: 
Purev E
Original Publication Date: 
Wednesday, June 11, 2014

We report a case of t(8;21) acute myeloid leukemia presenting as severe aplastic anemia. While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed metaphases, repeat bone marrow biopsy eight days later demonstrated this translocation. Initial cytogenetic analysis of 20 metaphases was therefore insufficient to make the diagnosis of hypocellular acute myeloid leukemia. We discuss that further complementary molecular tests, such as CGH, would likely provide a more robust diagnosis of hematopoietic diseases.

Bone Marrow Diseases: