Eculizumab: a guide to its use in paroxysmal nocturnal hemoglobinuria | Aplastic Anemia and MDS International Foundation

Eculizumab: a guide to its use in paroxysmal nocturnal hemoglobinuria

Journal Title: 
BioDrugs
Author(s): 
Keating GM, Lyseng-Williamson KA, McKeage K
Primary Author: 
Keating GM
Original Publication Date: 
Sunday, April 1, 2012

The targeted terminal complement inhibitor eculizumab (Soliris) reduces intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH), as well as stabilizing hemoglobin levels, improving fatigue and health-related quality of life, and reducing the requirement for packed red cell transfusions. Eculizumab is generally well tolerated in patients with PNH, although the risk of Neisseria meningitidis infection is increased with eculizumab, meaning that patients must be vaccinated.