A Marked Decrease in CD4-Positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-Associated Aplastic Anemia. | Aplastic Anemia and MDS International Foundation

A Marked Decrease in CD4-Positive Lymphocytes at the Onset of Hepatitis in a Patient With Hepatitis-Associated Aplastic Anemia.

Journal Title: 
J Pediatr Hematol Oncol
Author(s): 
Ikeda T, Morimoto A, Nakamura S, Yokoyama K, Hayase T, Oh Y, Kashii Y, Yotsumoto S, Okamoto H, Y Momoi M.
Primary Author: 
Ikeda T
Original Publication Date: 
Thursday, January 12, 2012

A 10-year-old Japanese boy developed acute hepatitis with high levels of serum Torque teno virus DNA and marked lymphocytopenia, especially CD4 T-lymphocytopenia. Although the total lymphocyte counts rose as the patient recovered from hepatitis, this was largely because of a marked rise in CD8 cells. In contrast, CD4 cells recovered poorly, resulting in a further striking fall in the CD4/8 ratio. Two months later, the patient developed hepatitis-associated aplastic anemia. He was successfully treated with immunosuppressive therapy, which normalized the lymphocyte subset proportions. T-cell subsets analysis at the onset of hepatitis might be useful for predicting development of hepatitis-associated aplastic anemia.

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