pure red cell aplasia (PRCA) | Aplastic Anemia and MDS International Foundation

pure red cell aplasia (PRCA)

Rational Management Approach To Pure Red Cell Aplasia

Author(s): 
Suresh Kumar Balasubramanian, Meena Sadaps, Swapna Thota, Mai Aly, Bartlomiej P. Przychodzen, Cassandra M. Hirsch, Valeria Visconte, Tomas Radivoyevitch, Jaroslaw P. Maciejewski
Primary Author: 
Maciejewski J
Journal Title: 
Haematologica
Original Publication Date: 
Dec 2017

Pure red cell aplasia is an orphan disease without rationally established standard therapies. Most cases are idiopathic; a subset is antibody-mediated. There is overlap between idiopathic cases and those with T-large granular lymphocytic leukemia, hypogammaglobulinemia, and low-grade lymphomas. In all these, the pathogenetic mechanisms may involve autoreactive cytotoxic responses.

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