paroxysmal nocturnal hemoglobinuria (PNH) | Page 17 | Aplastic Anemia and MDS International Foundation

paroxysmal nocturnal hemoglobinuria (PNH)

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Author(s): 
Risitano AM, Ricklin D, Huang Y, Reis ES, Chen H, Ricci P, Lin Z, Pascariello C, Raia M, Sica M, Del Vecchio L, Pane F, Lupu F, Notaro R, Resuello RR, Deangelis RA, Lambris JD
Primary Author: 
Risitano AM
Journal Title: 
Blood
Original Publication Date: 
Feb 2014

Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

Author(s): 
Krishnan SK, Hill A, Hillmen P, Arnold LM, Brooksbank GL, Wood A, Scarsbrook A, Davies MH, Kelly RJ
Primary Author: 
Krishnan SK
Journal Title: 
Int J Hematol
Original Publication Date: 
Dec 2013

A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

Author(s): 
Raza A, Ravandi F, Rastogi A, Bubis J, Lim SH, Weitz I, Castro-Malaspina H, Galili N, Jawde RA, Illingworth A.
Primary Author: 
Raza A
Journal Title: 
Cytometry B Clin Cytom
Original Publication Date: 
Nov 2013

BACKGROUND:
Paroxysmal nocturnal hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement activation leading to intravascular hemolysis and an inflammatory prothrombotic state. The EXPLORE study aimed to determine the prevalence of undiagnosed PNH in patients with aplastic anemia (AA), myelodysplastic syndrome (MDS), and/or other bone marrow failure (BMF) syndromes and the effect of PNH clone size on hemolysis.
METHODS:
Patients, selected from medical office chart reviews, had blood samples collected for hematologic panel testing and for flow cytometry detection of PNH clones.
RESULTS:

A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

Author(s): 
Raza A, Ravandi F, Rastogi A, Bubis J, Lim SH, Weitz I, Castro-Malaspina H, Galili N, Jawde RA, Illingworth A.
Primary Author: 
Raza A
Journal Title: 
Cytometry B Clin Cytom
Original Publication Date: 
Oct 2013

Background:

Polymorphism of the complement receptor 1 gene correlates with hematological response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

Author(s): 
Rondelli T, Risitano AM, Peffault de Latour R, Sica M, Peruzzi B, Ricci P, Barcellini W, Iori AP, Boschetti C, Valle V, Frémeaux-Bacchi V, De Angioletti M, Socié G, Luzzatto L, Notaro R.
Primary Author: 
Rondelli T
Journal Title: 
Haematologica
Original Publication Date: 
Sep 2013

Complement blockade by

The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood - a prospective study by EWOG-MDS.

Author(s): 
Aalbers AM, van der Velden VH, Yoshimi A, Fischer A, Noellke P, Zwaan CM, Baumann I, Beverloo HB, Dworzak M, Hasle H, Locatelli F, De Moerloose B, Göhring G, Schmugge M, Stary J, Zecca M, Langerak AW, van Dongen JJ, Pieters R, Niemeyer CM, van den Heuvel
Primary Author: 
Aalbers AM
Journal Title: 
Leukemia
Original Publication Date: 
Jun 2013

No abstract available.