myelodysplastic syndromes (MDS) | Page 102 | Aplastic Anemia and MDS International Foundation

myelodysplastic syndromes (MDS)

Cytogenetic response is not a prerequisite for clinical response in patients with myelodysplastic syndromes treated with azacitidine

Author(s): 
Gangatharan SA, Carney DA, Campbell LJ, Prince HM, Kenealy MK, Seymour JF.
Primary Author: 
Gangatharan SA
Journal Title: 
Eur J Haematol.
Original Publication Date: 
Aug 2011

No abstract available

Bone Marrow Diseases: 

Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)

Author(s): 
Malcovati L, Della Porta MG, Strupp C, Ambaglio I, Kuendgen A, Nachtkamp K, Travaglino E, Invernizzi R, Pascutto C, Lazzarino M, Germing U, Cazzola M.
Primary Author: 
Malcovati L
Journal Title: 
Haematologica.
Original Publication Date: 
Jun 2011

Background.

Bone Marrow Diseases: 

Clinical effect of point mutations in myelodysplastic syndromes

Author(s): 
Bejar R, Stevenson K, Abdel-Wahab O, Galili N, Nilsson B, Garcia-Manero G, Kantarjian H, Raza A, Levine RL, Neuberg D, Ebert BL.
Primary Author: 
Bejar R
Journal Title: 
N Engl J Med.
Original Publication Date: 
Jun 2011

BACKGROUND:

Myelodysplastic syndromes are clinically heterogeneous disorders characterized by clonal hematopoiesis, impaired differentiation, peripheral-blood cytopenias, and a risk of progression to acute myeloid leukemia. Somatic mutations may influence the clinical phenotype but are not included in current prognostic scoring systems.

METHODS:

We used a combination of genomic approaches, including next-generation sequencing and mass spectrometry-based genotyping, to identify mutations in samples of bone marrow aspirate from 439 patients with myelodysplastic syndromes. We then examined whether the mutation status for each gene was associated with clinical variables, including specific cytopenias, the proportion of blasts, and overall survival.

RESULTS:

Bone Marrow Diseases: