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Newsstand

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

Study suggests heart drugs may boost chemotherapy in AML

Originally Published: 09/05/2017
Scientists may have identified a way to boost the effect of chemotherapy against one of the most common forms of leukemia in adults: acute myeloid leukemia. In a new study, researchers found that acute myeloid leukemia (AML) triggers blood vessel leakage in bone marrow, which prevents chemotherapy drugs from being effectively delivered to leukemia cells. However, by using drugs normally used to treat heart and blood vessel disease, the researchers found that they were able to prevent this blood leakage and increase the efficacy of chemotherapy. First study author Diana Passaro, of the...

Allogeneic transplant: does age still matter?

Originally Published: 08/31/2017
In this issue of Blood, on behalf of the Center for International Blood and Marrow Transplant Research (CIBMTR), Muffly et al report on the incidence and outcome of allogeneic stem cell transplantations (alloSCTs) performed between 2000 and 2013 in 1106 patients aged ≥70 years. The incidence of alloSCT in this age group accounted for 0.1% of all stem cell transplantations (SCTs) reported to the CIBMTR in 2001, and it rose to 3.85% by 2013. Comparison of 2 time periods of performing SCTs, 2000 to 2007 and 2008 to 2013, revealed significant improvement in overall survival (OS) and progression-...

FDA approves new drug for relapsed or refractory AML

Originally Published: 08/30/2017
On August 1, 2017, the U.S. Food and Drug Administration granted regular approval to enasidenib (IDHIFA, Celgene Corp.) for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 (IDH2) mutation as detected by an FDA-approved test. This is the first FDA approval for relapsed or refractory AML specifically with an IDH2 mutation. The FDA concurrently approved a companion diagnostic, the RealTime IDH2 Assay, used to detect the IDH2 mutation. The enasidenib approval was based on Study AG221-C-001 (NCT01915498), an open-label, single-...

New treatment approved for certain high-risk AML

Originally Published: 08/30/2017
The U.S. Food and Drug Administration today approved Vyxeos for the treatment of adults with two types of acute myeloid leukemia (AML): newly diagnosed therapy-related AML (t-AML) or AML with myelodysplasia-related changes (AML-MRC). Vyxeos is a fixed-combination of chemotherapy drugs daunorubicin and cytarabine. “This is the first approved treatment specifically for patients with certain types of high-risk AML,” said Richard Pazdur, M.D., director of the FDA’s Oncology Center of Excellence and acting director of the Office of Hematology and Oncology Products in the FDA’s Center for Drug...

Marrow protein may be key to SCT success

Originally Published: 08/29/2017
Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during systemic infection, creating new blood cells, including immune cells, in a process known as hematopoiesis. A new study led by University of Pennsylvania and Technical University of Dresden scientists has identified an important regulator of this process, a protein called Del-1. Targeting it, the researchers noted, could be an effective way to improve stem cell transplants for both donors and recipients. There...

MDS Update - August 2017

Originally Published: 08/29/2017
MDS Update - August 2017

FDA approves first drug to treat GVHD

Originally Published: 08/24/2017
A drug currently used to treat several forms of blood cancer, ibrutinib (Imbruvica®), has been approved by the Food and Drug Administration (FDA) for the treatment of chronic graft-versus-host disease (cGVHD). The agency’s decision, announced on August 2, makes ibrutinib the first approved therapy for this potentially fatal and common side effect of cancer-related stem cell transplants. The approval covers the use of ibrutinib in patients with cGVHD that is not responding to other standard treatments, namely corticosteroids. Ibrutinib is already approved by FDA for the treatment of several...

Top honor goes to AAMDSIF Medical Advisor

Originally Published: 08/24/2017
The American Society of Hematology (ASH) will present the 2017 William Dameshek Prize to Benjamin L. Ebert, MD, PhD, of Harvard Medical School, Brigham and Women’s Hospital, and Dana-Farber Cancer Institute for his seminal discoveries in multiple areas of non-malignant and malignant hematology. The William Dameshek Prize is awarded to an early- or mid-career hematologist who has made a recent outstanding contribution to the field of hematology. This prize is named after the late William Dameshek, MD, a past president of ASH and the original editor of Blood. ASH President Kenneth C. Anderson...

New study on SCT therapy for SAA, MDS patients

Originally Published: 08/21/2017
Gamida Cell announced today that an investigator-initiated study testing their candidate CordIn, to treat severe aplastic anemia (AA) or hypoplastic myelodysplastic syndrome (MDS) has begun, and the first patient was given the drug. Severe AA is a condition in which the bone marrow does not produce enough blood cells for the body, and hypoplastic MDS is characterized by decreased marrow cellularity. Cordin is a variety of stem cell transplantation that uses blood from an umbilical cord. It is a curative treatment in development for an array of rare diseases, including sickle cell disease,...

Foundation Update - August 2017

Originally Published: 08/16/2017
Foundation Update Newsletter - August 2017 Unique Aplastic Anemia Protocol at NIH In December 2016 we presented the story of John Vasquez, a San Antonio resident who had been recently accepted at NIH for treatment. John is now part of a research study in which he is the first aplastic anemia patient to be treated with a particular stem cell transplant protocol. The transplant occurred on August 11 and in coming months, we'll be following John's ongoing story – including the particulars of this clinical trial and his family's support, all as parts of his...