Paroxysmal Nocturnal Hemoglobinuria
Drugs that are considered standard and investigational therapies for paroxysmal nocturnal hemoglobinuria (PNH) are listed below, please click on their names for more information:
Generic Name | Brand Name |
Darbepoetin alfa (Aranesp) promotes red blood cell production and is known as a growth factor. Growth factors are normal chemicals in the body that encourage the bone marrow to make blood cells. Growth factors have been manufactured as drugs to stimulate the bone marrow to produce more blood cells. darbepoetin alfa
| (Aranesp) |
Eculizumab is in a class of drugs called monoclonal antibodies. This drug blocks the effects of serum proteins ("complement") and stops hemolysis, the destruction of blood cells. Eculizumab is in clinical studies to determine its effectiveness and safety in reducing the need for blood transfusions in paroxysmal nocturnal hemoglobinuria (PNH) patients. eculizumab
| (Soliris) |
Epoetin alfa (Epogen, Procrit) promotes red blood cell production in the bone marrow and is known as a growth factor. Growth factors are normal chemicals in the body that encourage the bone marrow to make blood cells. Growth factors have been manufactured as drugs to stimulate the bone marrow to produce more blood cells. epoetin alfa
| (Erythropoietin) |
Filgrastim (G-CSF) and Sargramostim (GM-CSF) promote white cell growth in the bone marrow and are known as hematopoietic (blood forming) growth factors or colony stimulating factors. They are a man-made (synthetic) version of the colony stimulating factors produced naturally in your body. These drugs are prescribed "off label" for patients with MDS and other patients with low white cell counts (neutropenia). filgrastim (G-CSF)
| (Neupogen) |
Prednisone, a corticosteroid, is a man-made (synthetic) version of a hormone produced naturally by your adrenal gland. It is prescribed when your body is not producing enough of this chemical on its own. prednisone
| (numerous names) |
Filgrastim (G-CSF) and Sargramostim (GM-CSF) promote white cell growth in the bone marrow and are known as hematopoietic (blood forming) growth factors or colony stimulating factors. They are a man-made (synthetic) version of the colony stimulating factors produced naturally in your body. These drugs are prescribed "off label" for patients with MDS and other patients with low white cell counts (neutropenia). sargramostim (GM-CSF)
| (Leukine) |
The information contained on these pages is not comprehensive. It should not be considered medical advice and does not take the place your physician's advice. Although AA&MDSIF strives to provide accurate and up-to-date information, it does not guarantee the accuracy or currency of this information.
